ID C5MJB0_CANTT Unreviewed; 325 AA.
AC C5MJB0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dihydroceramide delta(4)-desaturase {ECO:0000313|EMBL:EER30369.1};
GN ORFNames=CTRG_06153 {ECO:0000313|EMBL:EER30369.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER30369.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER30369.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; GG692405; EER30369.1; -; Genomic_DNA.
DR RefSeq; XP_002546675.1; XM_002546629.1.
DR AlphaFoldDB; C5MJB0; -.
DR STRING; 294747.C5MJB0; -.
DR EnsemblFungi; CTRG_06153-t43_1; CTRG_06153-t43_1-p1; CTRG_06153.
DR GeneID; 8300014; -.
DR KEGG; ctp:CTRG_06153; -.
DR VEuPathDB; FungiDB:CTRG_06153; -.
DR eggNOG; KOG2987; Eukaryota.
DR HOGENOM; CLU_032156_0_1_1; -.
DR OrthoDB; 5485164at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042284; F:sphingolipid delta-4 desaturase activity; IEA:UniProtKB-EC.
DR GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro.
DR CDD; cd03508; Delta4-sphingolipid-FADS-like; 1.
DR InterPro; IPR011388; DES1/DES2.
DR InterPro; IPR005804; FA_desaturase_dom.
DR PANTHER; PTHR12879; SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2; 1.
DR PANTHER; PTHR12879:SF8; SPHINGOLIPID DELTA(4)-DESATURASE DES1; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..280
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
SQ SEQUENCE 325 AA; 38149 MW; 6A632A159938DDB6 CRC64;
MIMQKYPEVR KLTGYEPKTK WYVIGIVLLQ ISIAFYLRKT PVLSWKFFIL AYVIGATANQ
AIFLAIHELS HNLLFKKPIH NKLFAIFTNI PIGVPYSASF QPYHQLHHKF LGDKYLDTDL
PTRIEAIILS NPLGKTFFAT CQIFFYALRP MFITQIKFTY IHLLNVMFQL IFDHFMVKYL
GWKALGYFIM STFLAGSLHP CAGHFIAEHY VLNENNVPRG EMIKGTNISK ELLPAETYSY
YGSLNLLTWN VGYHNEHHDF PYIAWTKLPE LRKIAPEFYD PLPQVTSWCG VIWWFITHDV
NRVWNRVKRD GKEKHGYKIE KLDEN
//
