ID C5S154_9PAST Unreviewed; 317 AA.
AC C5S154;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Magnesium transport protein CorA {ECO:0000256|ARBA:ARBA00019439, ECO:0000256|RuleBase:RU362010};
GN Name=corA {ECO:0000256|RuleBase:RU362010};
GN ORFNames=AM305_08159 {ECO:0000313|EMBL:EER47285.1};
OS Actinobacillus minor NM305.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=637911 {ECO:0000313|EMBL:EER47285.1, ECO:0000313|Proteomes:UP000005532};
RN [1] {ECO:0000313|EMBL:EER47285.1, ECO:0000313|Proteomes:UP000005532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NM305 {ECO:0000313|EMBL:EER47285.1,
RC ECO:0000313|Proteomes:UP000005532};
RX PubMed=19819087; DOI=10.1016/j.vetmic.2009.09.030;
RA Arya G., Niven D.F.;
RT "Production of haemolysins by strains of the Actinobacillus
RT minor/"porcitonsillarum" complex.";
RL Vet. Microbiol. 141:332-341(2010).
CC -!- FUNCTION: Mediates influx of magnesium ions (By similarity). Alternates
CC between open and closed states. Activated by low cytoplasmic Mg(2+)
CC levels. Inactive when cytoplasmic Mg(2+) levels are high.
CC {ECO:0000256|ARBA:ARBA00034294}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827,
CC ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00034269};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362010}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362010}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|RuleBase:RU362010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER47285.1}.
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DR EMBL; ACQL01000085; EER47285.1; -; Genomic_DNA.
DR RefSeq; WP_005823479.1; NZ_ACQL01000085.1.
DR AlphaFoldDB; C5S154; -.
DR eggNOG; COG0598; Bacteria.
DR OrthoDB; 9803416at2; -.
DR Proteomes; UP000005532; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd12835; EcCorA-like_1; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR NCBIfam; TIGR00383; corA; 1.
DR PANTHER; PTHR47685; MAGNESIUM TRANSPORT PROTEIN CORA; 1.
DR PANTHER; PTHR47685:SF1; MAGNESIUM TRANSPORT PROTEIN CORA; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU362010};
KW Ion transport {ECO:0000256|RuleBase:RU362010};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362010};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362010};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362010}; Transport {ECO:0000256|RuleBase:RU362010}.
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
SQ SEQUENCE 317 AA; 36710 MW; C21B541FD1DFFEA1 CRC64;
MIRAFALDNA RLVSVDETSK DQLNDSIWID LIDPSDDERS VLKLGLDQTL AEEHELEDLE
ASARFFEDED GLHLHSFFYC LDDDDYADIA TVAFTIRDGR LFTLRERDLP AFRLYRMRSR
RAKLLDSNAY ELLLDLFETK IEQLADVIET VYADLENFSH IILDGKQEGN SLNEALSDLT
ELEDVSSKVR LCLMDTQRAL SFLLRKTRLP NNQLEQARDI MRDIESLQPH NESLFQKVNF
LMQAAMGYIN IEQNKIMKFF SVVSVMFLPA TLVASTYGMN FEFMPELHFK YGYPMAIGLM
ICAAATPYIY FRRKGWL
//
