ID C5X8J8_SORBI Unreviewed; 803 AA.
AC C5X8J8;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SORBI_3002G304500 {ECO:0000313|EMBL:EER99382.2};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:EER99382.2, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:EER99382.2, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; CM000761; EER99382.2; -; Genomic_DNA.
DR AlphaFoldDB; C5X8J8; -.
DR STRING; 4558.C5X8J8; -.
DR EnsemblPlants; EER99382; EER99382; SORBI_3002G304500.
DR Gramene; EER99382; EER99382; SORBI_3002G304500.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_019628_2_0_1; -.
DR InParanoid; C5X8J8; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000000768; Chromosome 2.
DR ExpressionAtlas; C5X8J8; baseline.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:EnsemblPlants.
DR GO; GO:0043073; C:germ cell nucleus; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:EnsemblPlants.
DR GO; GO:0010777; P:meiotic mismatch repair involved in reciprocal meiotic recombination; IEA:EnsemblPlants.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768}.
FT DOMAIN 200..541
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 556..743
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
SQ SEQUENCE 803 AA; 89551 MW; C82F7102597481FE CRC64;
MEGDAAGADG GGGGGGERSS FVIGLIENRA KEVGVAAFDL RSASLHLSQY IETGCSYHNT
RTLLHFYDPM VVIVPPNKTA ADGMVGVSEL IDKHYPANKK VTMARGCFDD TKGAGIVKSL
SARDPSALGL DTYCKQYYLC LAAVTATIKW IESEKGVFIT NHSLSVTFNG SFDHMSIDST
SVQTLEIIDP LHTELWGTSN KKKSLFQMLK TTKTTGGARL LRANLLQPLK DIQTINARLG
CLDELMSNEE LFFGLTQGLR KFPKESDKVL CHFCFKPKKV RDEVLKPANG RKSQKLISDI
IVLKTALDAI PFLSKVLKGA KSVLLHNIYQ TVCENPKYAN MRKRIGDVID EDVVHSRAPF
VACTQECFAV KAGIDGLLDV ARRSFCDTSE AVHNLAKQYR EEYNMPNLKM PYNTRQGFYF
MIPQKDITDR LPNKFIQVVR HGKNIHCSSL ELASLNVRNK TAAAECFSRT ELCLEGLIDE
IRGDIGILTL LAEVLCLLDM IVNSFAHTIS TKPVDRYTRP EFTDDGPMAI NAGRHPILET
LRTDFVPNDI FLSEASNMVL IMGPNMSGKS TYLQQICLIV ILAQIGCYVP AQFASLRVVD
RIFTRIGNGD NVENNSSTFM TEMKETAFIM QNVTSRSLVV VDELGRATSS SDGLAIAWSC
CEYLLSVKAY TVFATHMERL SELATMYPNV KILHFEVDLR NDRLDFKFRL KDGVRRVPHY
GLLLARVAGI PTSVIDTSTS ITSQITEQEM TRMDANCEEY RSLQMTYQVV QRLICLKYSN
HDEDYIREAL QNLKESYAAG RLT
//
