ID C5Z757_SORBI Unreviewed; 328 AA.
AC C5Z757;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
GN ORFNames=SORBI_3010G212200 {ECO:0000313|EMBL:EER88747.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:EER88747.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:EER88747.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
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DR EMBL; CM000769; EER88747.1; -; Genomic_DNA.
DR RefSeq; XP_002437380.1; XM_002437335.1.
DR AlphaFoldDB; C5Z757; -.
DR STRING; 4558.C5Z757; -.
DR EnsemblPlants; EER88747; EER88747; SORBI_3010G212200.
DR GeneID; 8058438; -.
DR Gramene; EER88747; EER88747; SORBI_3010G212200.
DR KEGG; sbi:8058438; -.
DR eggNOG; KOG1431; Eukaryota.
DR HOGENOM; CLU_007383_18_0_1; -.
DR InParanoid; C5Z757; -.
DR OMA; HPSNYGY; -.
DR OrthoDB; 5474548at2759; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000000768; Chromosome 10.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IBA:GO_Central.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05239; GDP_FS_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768}.
FT DOMAIN 21..253
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 328 AA; 35765 MW; 7B9A4F11DBA23AF1 CRC64;
MGTVTAADPH PSFLADKDAK VFVAGHRGLV GSAIVRRLLS LGFTSVVVRT HAELDLTRQA
DVEAFFAAER PRYVVLAAAK VGGIHANSTY PADFIAANLQ IQTNVVDAAL RCVSVRKLLF
LGSSCIYPKF APQPITEGAL LSGPLEPTNE WYAVAKIAGI KMCQAYRIQH GLDAVSAMPT
NLYGPHDNFH PENSHVLPAL IRRFHEAKAT NAPEVVVWGS GSPLREFLHV DDLADGVIFL
MEHYSGLEHV NVGSGSEVTI KELAELVKEV VGFQGNLVWD SSKPDGTPRK LMDSSKIQGM
GWKPKIALKE GLIETYKWYV ENVISNKK
//