ID C5ZYY9_9HELI Unreviewed; 596 AA.
AC C5ZYY9;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HCAN_0530 {ECO:0000313|EMBL:EES89247.1};
OS Helicobacter canadensis MIT 98-5491.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=537970 {ECO:0000313|EMBL:EES89247.1, ECO:0000313|Proteomes:UP000007032};
RN [1] {ECO:0000313|EMBL:EES89247.1, ECO:0000313|Proteomes:UP000007032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13241 {ECO:0000313|Proteomes:UP000007032};
RX PubMed=19542273; DOI=10.1128/JB.00729-09;
RA Loman N.J., Snyder L.A., Linton J.D., Langdon R., Lawson A.J.,
RA Weinstock G.M., Wren B.W., Pallen M.J.;
RT "Genome sequence of the emerging pathogen Helicobacter canadensis.";
RL J. Bacteriol. 191:5566-5567(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000776; EES89247.1; -; Genomic_DNA.
DR RefSeq; WP_006655224.1; NZ_DS990368.1.
DR AlphaFoldDB; C5ZYY9; -.
DR STRING; 537970.HCAN_0530; -.
DR REBASE; 42000; M.Hca5491ORF530P.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_0_2_7; -.
DR OrthoDB; 9761012at2; -.
DR Proteomes; UP000007032; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 2.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EES89247.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007032};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EES89247.1}.
FT DOMAIN 9..99
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 137..228
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 238..558
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 562..589
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 596 AA; 68757 MW; DC1A6176E3D751EB CRC64;
MNDIQQKKLG STLWAIADKL RGAMNADDFR DYMLSFLFLR YLSDNYEEAV KKELGSDYHK
SELEIQKNGA NQDAYIDELK NIIIKHSNSL SPKELGLQED EKDQEKIKKA RQDFIDYNNK
MLYSHNVIPL AVWYIRNLDQ VDMLEKQMRR KIHYVIKPAY LWSNIYELAR TQNSQLLKTL
QRGFKYIENE SFESRFRGLF SEVNLDSDKL GKNYSERNIL LCQVITEIAQ GLSKFPNETD
LLGDAYEYLI GQFAAGSGKK AGEFYTPQQV STILSRIVSL DSQDPSTGKK SKLKNILDFA
CGSGSLLINV RKQFGANSIG QIYGQEKNIT TYNLARMNML LHGVKDSEFQ IHHGDSLLND
WNILNEMNPA KKMQFEVVVA NPPFSYRWQP KEEMAEDFRF KNYGLAPKSA ADFAFLLHGF
HFLSDDGTMA IILPHGVLFR GGVEEKIRTK LLEDGNIDAI IGLPANLFFS TGIPVCVLVL
KKCKKYDDVL IINASEYFEK GKRQNILLPE HIDKIIETYQ YRKEDDKKYS RRVSMKEIKK
NGYNLNISRY VSTAPEEEIV DIEEVWDELE KIENEIKKAK AKHNEFLKEL GLKLIP
//
