ID C6A0M4_THESM Unreviewed; 766 AA.
AC C6A0M4;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Replication factor C small subunit {ECO:0000256|ARBA:ARBA00014164};
DE AltName: Full=Clamp loader small subunit {ECO:0000256|ARBA:ARBA00031749};
GN OrderedLocusNames=TSIB_0101 {ECO:0000313|EMBL:ACS89169.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS89169.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS89169.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcS
CC subfamily. {ECO:0000256|ARBA:ARBA00009668}.
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DR EMBL; CP001463; ACS89169.1; -; Genomic_DNA.
DR RefSeq; WP_012766130.1; NC_012883.1.
DR AlphaFoldDB; C6A0M4; -.
DR STRING; 604354.TSIB_0101; -.
DR MEROPS; N10.007; -.
DR GeneID; 8095070; -.
DR KEGG; tsi:TSIB_0101; -.
DR eggNOG; arCOG00469; Archaea.
DR HOGENOM; CLU_015698_2_0_2; -.
DR OrthoDB; 7928at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 2.
DR CDD; cd00081; Hint; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013748; Rep_factorC_C.
DR InterPro; IPR047854; RFC_lid.
DR InterPro; IPR008824; RuvB-like_N.
DR NCBIfam; TIGR01443; intein_Cterm; 1.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR PANTHER; PTHR11669:SF5; REPLICATION FACTOR C SUBUNIT 2; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR Pfam; PF08542; Rep_fac_C; 1.
DR Pfam; PF05496; RuvB_N; 1.
DR PRINTS; PR00379; INTEIN.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000};
KW Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 241..388
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 500..524
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
SQ SEQUENCE 766 AA; 86954 MW; 20A79161DDF6AD47 CRC64;
MVEEVKEVKE VKILEKPWVE KYRPERLDDI VGQDHIVKRL KHYVKTASMP HLLFAGPPGT
GKTTSSLALA RELFGEHWRH NFLELNASVS KDTPILVRIN GRVMRTTFAE LDKLYFNESD
GEVAYKDASN LEVLTVDENY CVKWAQVSKI IRHHVPVILH VHLEGGGKLE LTGNHSVMVL
TENGLETVKA SELKEGTILL SFTTNIEGFL DVLDMSDYSI KESARTRTFK GLSVDEELSY
IFGLYAAEGA VGFNGNTSGQ VIYTLGSHEG QLIERIKAFV ENLGVSVYEN YTSSGFDRSR
KSAYQFRLLN TQLARFFEES FYDGNGRRAN NKRLPGFVFE FPIRERIAFL KGLADGDGTG
EWGGVIRVSS VSRDLLIDTV WLARVSGIEA SLFEREARLI WKGGMKWSKA ELLPAEPIVK
MLEAIENAIE GNWRYEFRHQ LYEGKKRVRK ATLRKAIEMV NEEKLDEKGK RILEVLKKLA
NTDLHALLVR KIELVEYNDF VYDVSVPGNE MFFAGEIPVL LHNSDERGIN VIREKVKEFA
RTKPIGGVSF KIIFLDEADA LTQDAQQALR RTMEMFSSNV RFILSCNYSS KIIEPIQSRC
AIFRFRPLKD EDVARRLKYI AENEGLELTE EGLQAILYVA EGDLRRAINV LQAAAALDTR
ITDENVFLVA SRARPEDVRE MMLLALEGNF LKARDKLREI LLKQGLSGED VLIQMHKEVF
NLPISEPKKV ALADKIGEYN FRLVEGSNEM IQLEALLAQF TLLGKD
//