ID C6A1X8_THESM Unreviewed; 532 AA.
AC C6A1X8;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=TSIB_0558 {ECO:0000313|EMBL:ACS89623.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS89623.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS89623.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the HerA family.
CC {ECO:0000256|ARBA:ARBA00007816}.
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DR EMBL; CP001463; ACS89623.1; -; Genomic_DNA.
DR RefSeq; WP_015848843.1; NC_012883.1.
DR AlphaFoldDB; C6A1X8; -.
DR STRING; 604354.TSIB_0558; -.
DR GeneID; 8095546; -.
DR KEGG; tsi:TSIB_0558; -.
DR eggNOG; arCOG00280; Archaea.
DR HOGENOM; CLU_023842_2_0_2; -.
DR OrthoDB; 107033at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR018538; HerA_barrel_dom.
DR InterPro; IPR002789; HerA_central.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42957; HELICASE MJ1565-RELATED; 1.
DR PANTHER; PTHR42957:SF1; HELICASE MJ1565-RELATED; 1.
DR Pfam; PF01935; DUF87; 1.
DR Pfam; PF09378; HAS-barrel; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 14..108
FT /note="Helicase HerA barrel"
FT /evidence="ECO:0000259|Pfam:PF09378"
FT DOMAIN 144..360
FT /note="Helicase HerA central"
FT /evidence="ECO:0000259|Pfam:PF01935"
SQ SEQUENCE 532 AA; 60341 MW; E72F8A5AB95F7895 CRC64;
MPEITGELGS FEKIGVVVGE TTHSEFYFAI EDTKTPQIWD YVVVRSKEVV DGTEKDVLVL
GQIVAITSYS PGLSEYTPYP VAEKLKDAEI IEPRNFAQVK VLGFTVGGKV LMPRRTIYPG
TDVYLAPDDV LSQVYSYPDE EGLFIGHLIT RPRVKVQLTI RGFRRHLAIL AQTGAGKSYT
AGVLLEELYD KGATVIVLDP HADYVFISQS KDGKRILPRV DVFRTRESTG RYTKEDIGHM
ETFEIKFSDL SPDEIFTITG IRDEWLNIQK AVRDAVKELK NEKPGRYTVE DLINKLESMD
SNDSLRAIKY IEKLKGLKVF GEVTTPIENL LKPQHISVMD LSGLSDHVAD YIAYKILSEV
YYQREHGKYK YPVFVLVEEA HRFIPKKENT LSKRIAKRIA AEGRKFGVFL ILLTQRPQKI
DQDVLSQCNS QIIMRMTNPE DQKAVRASAE QVSEDLLNDL PGLNVGEAVI VGEMTKMPVM
VKIRERKTKE GGADIDIVTR LSEALKEAKE YEESKDEIIR EEIKEIRDIL DM
//
