ID C6A2U5_THESM Unreviewed; 354 AA.
AC C6A2U5;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Saccharopine reductase {ECO:0000313|EMBL:ACS89940.1};
GN OrderedLocusNames=TSIB_0881 {ECO:0000313|EMBL:ACS89940.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS89940.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS89940.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
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DR EMBL; CP001463; ACS89940.1; -; Genomic_DNA.
DR RefSeq; WP_015849159.1; NC_012883.1.
DR AlphaFoldDB; C6A2U5; -.
DR STRING; 604354.TSIB_0881; -.
DR GeneID; 8095872; -.
DR KEGG; tsi:TSIB_0881; -.
DR eggNOG; arCOG00243; Archaea.
DR HOGENOM; CLU_032858_3_0_2; -.
DR OrthoDB; 27588at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR PANTHER; PTHR11133:SF22; SACCHAROPINE DEHYDROGENASE [NADP(+), L-GLUTAMATE-FORMING]-RELATED; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 3..112
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 117..344
FT /note="Saccharopine dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16653"
SQ SEQUENCE 354 AA; 40282 MW; 781921B01105CCBB CRC64;
MKICVLGAGD VGRLIAYDLS KDYEVSIADK SKERLKLAEN FATTYELDAS KFEDLVEFMK
KFDLIVGALP GRFGFSTLKA AIKARRDIVD VSFMPEDPLE LDDQAKEAGI RMVVDAGFAP
GLSNILMGHI QAVLGKLDEG VINVGGLPKN PQPPLYYKVV FSPYDLIEEY TRPARIIRNG
RLVRVDPLED IKQLKIRDFE FESFVSDGLR TLLATIEAEN LYENTLRWKG HLEKMKVLKE
LGFFNPENIE FTMKVILPLM QFESDDFSIM EVYGKSGEQE MRYFMYDEAQ GGFTSMARST
GYITAITARL VLKYEFEPGV IPPELFGMED DLFDEIIKEV KKRNIVLEEY HKGL
//
