ID C6A3S8_THESM Unreviewed; 278 AA.
AC C6A3S8;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tyrosine recombinase XerA {ECO:0000256|HAMAP-Rule:MF_02055};
GN Name=xerA {ECO:0000256|HAMAP-Rule:MF_02055};
GN OrderedLocusNames=TSIB_1219 {ECO:0000313|EMBL:ACS90273.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS90273.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS90273.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules.
CC {ECO:0000256|HAMAP-Rule:MF_02055}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02055}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerA subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_02055}.
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DR EMBL; CP001463; ACS90273.1; -; Genomic_DNA.
DR RefSeq; WP_015849492.1; NC_012883.1.
DR AlphaFoldDB; C6A3S8; -.
DR STRING; 604354.TSIB_1219; -.
DR GeneID; 8096217; -.
DR KEGG; tsi:TSIB_1219; -.
DR eggNOG; arCOG01241; Archaea.
DR HOGENOM; CLU_027562_9_5_2; -.
DR OrthoDB; 142231at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR HAMAP; MF_02055; Recomb_XerA; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR033686; XerA.
DR NCBIfam; NF040815; recomb_XerA_Arch; 1.
DR PANTHER; PTHR30349:SF41; INTEGRASE_RECOMBINASE HI_1414-RELATED; 1.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02055};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP-
KW Rule:MF_02055};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_02055};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_02055}; Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 1..76
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 92..268
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT ACT_SITE 129
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
FT ACT_SITE 154
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
FT ACT_SITE 220
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
FT ACT_SITE 223
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
FT ACT_SITE 246
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
FT ACT_SITE 255
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02055"
SQ SEQUENCE 278 AA; 32150 MW; 787675E51479A018 CRC64;
MNDGIEEFKT YLELEGKSPQ TVRMYTYYVE RFLKDVENPN YRSALRFLAK LKKEGYSNKS
LNLVVQALKS YFRFEGLDED AEKLKSPKVP RSLPKSLTRE DVKRLLNAVP PTRKRDRLII
LLLYGTGLRV SEVCNLKIKD IDFNRGVLTV EGGKGAKDRI VPLSGSLLKE IEKYLETRKD
GSEYLFVEIR REKKDKISPK TVWYLLKKYG NKANVSVTPH MLRHSFATHM LERGVDIRVI
QEILGHSSLS TTQIYTKVTV EHLKKAQEKA KLIDELIE
//