ID C6A4H7_THESM Unreviewed; 405 AA.
AC C6A4H7;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=2-ketoglutarate:ferredoxin oxidoreductase (KGOR), subunit alpha {ECO:0000313|EMBL:ACS90522.1};
DE EC=1.2.7.3 {ECO:0000313|EMBL:ACS90522.1};
GN OrderedLocusNames=TSIB_1471 {ECO:0000313|EMBL:ACS90522.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS90522.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS90522.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
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DR EMBL; CP001463; ACS90522.1; -; Genomic_DNA.
DR RefSeq; WP_015849739.1; NC_012883.1.
DR AlphaFoldDB; C6A4H7; -.
DR STRING; 604354.TSIB_1471; -.
DR GeneID; 8096476; -.
DR KEGG; tsi:TSIB_1471; -.
DR eggNOG; arCOG01607; Archaea.
DR HOGENOM; CLU_017038_0_1_2; -.
DR OrthoDB; 31112at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR43088; SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR43088:SF1; SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01855; POR_N; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ACS90522.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009079}.
FT DOMAIN 34..270
FT /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT pyrimidine binding"
FT /evidence="ECO:0000259|Pfam:PF01855"
FT DOMAIN 294..388
FT /note="Pyruvate:ferredoxin oxidoreductase core"
FT /evidence="ECO:0000259|Pfam:PF17147"
SQ SEQUENCE 405 AA; 45245 MW; 85B7B02791529319 CRC64;
MIIRGDEPEQ IRLLKKMYPK GNYFMQGDEA IAYGALFAGC RFYAGYPITP ASEIAETMAR
ELPKLKGYYI QMEDEIGSIA AVVGASWTGF KSMTATSGPG FSLMQENLGY AIFTETPLVL
VDVQRSGPST GQATKGAQGD FFQARWGTHG DHPIIAISPT SVEDSFWETI RAFNLSEKFR
IPVLVLADGI IGHTREQINI PDPEEVEIVY RKLPTSDEEA KYPFGDVHGD LIPPMPLFGH
GYFTHVTGST HKENGLRDVY TPEVHDRLVR RLHKKIEIHK AEIQKWEEYY VEDAEILLVS
WGVSARPSLG AVMKARKKGI KVGLFVPKTV HPFPGERIKE LSKNVQLIIV PEMNLGQVIL
EVQRFVRDEV PVIGVNKIGG VPLTVEEILK EIESSAERSR HRSAD
//
