ID C6HCQ1_AJECH Unreviewed; 2478 AA.
AC C6HCQ1;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Nonribosomal peptide synthase SidE {ECO:0000313|EMBL:EER42341.1};
GN ORFNames=HCDG_03800 {ECO:0000313|EMBL:EER42341.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER42341.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG692422; EER42341.1; -; Genomic_DNA.
DR STRING; 544712.C6HCQ1; -.
DR VEuPathDB; FungiDB:HCDG_03800; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_0_12_1; -.
DR OMA; ECTQLNW; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 915..994
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1922..1998
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1906..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2478 AA; 276220 MW; DFE531A436D0C3FE CRC64;
MVISESQEEI QCTGQQRKYL SQTITGNQPT YVLRWNTHQL CPSIDRLVYT WQAVASHNPV
LRTSIKYSGT DQEPRLVVLR RAAPIRIEGF SNRGAYKSSS LKTAELTVIL SETSVSFRLR
ILQALVDRRS LALICRDFDL FYQGLSCEPH DHFKYYISHI AQRETQNAES YWRNLMNGSV
TSLSYGFPTN ISGMRKTFIS DLHEILVRSI YDFLGVYSVS ARDFVHALWS LVQYRHTAAT
DGTTFFAVTG RDTSVPGFDT VVGPAELYYP LKVVIENDLS LLSWIRKVSK IDQQASQNAY
IGYDKIQDQI LPLKAQVCIT VSDSLDIIEE GDCDIRFPLA INVDLERHLV NMEYYSETSE
DHDLQVIFNH FIALVEEAIR DPKAIVSGID IVPKEEREFL LRCSQPVTLP ATGLIHELFE
RQAELNPQHE CLNFEGQMDF TYGELNKLSN QVARQLGCGR GDYVPICMDR SPALIVSILA
ILKTGAAYVI LDPESPVERN SFIVTDVQAP FVITDRISAI NFAYPLLIET LIALTPRFDG
SNMAVCQEAT DICYVIYTSG STGKPKGVLL EHKSAYTGLM AFPTLPNLRQ LLFHNPIFSA
AQRSIFSTLK QGGCLCLAKK ENLTVRITEM INSMRVNVID VTPSTATLID QTRVPTLRRM
TVAGELINPA LLPVWMDKLE LLNAYGLSEV TQINWRHVMH PMQNPQNIGR PVDSTRSYVL
VPGTTQLAAI LEPGELCLGG HQLARSYLNR PEKTRESFIQ NPFGPGRLYR TGDMVVTHAD
GSIEMIGRID FQVKINGQRV EPGEVNCYIQ QHPDVFDSWT VSATIGNQKS LVAVVVPRDE
RDWSTLVQSL QKILRDCVPS YMVPAYWWKR DRLPLNVNGK VDVSLLCRLV EAIPLEELII
RSIAQSQHIN QCQLTPMESS LRRIWAEVLH LPESSINLED SFLNLGGSSL SAIVAASRAN
NELIEVKVHD ILLQTVCLNY IVPNGIEDAW PSTPSQEPLI ADVMLGGTKY LYDRVVTLKD
TSNDEVKAAL KKLLEADSFL RSTFTPYGTT YLQTIPKESP LPWQELDMKL AEYLEKRPVT
VAMGGPFFKV TALSTGELVF TMHHALFDFW SSRFIFDDLS NLIRTRPLAN RPKYNKLVQY
LSQKDKTSSQ QYWRNYLKDS KTSRLGHTPG PNTITKLNLK TPIPSTSKTI GVSTGSILYA
SWALVLSHVL GSSEVIFGIT LFGRDVPIPD VLLMEGPAVL QVPLRVKISK SSSIGKVAKD
IHTQIKSVVD HAHYGLRNIL LAAGQPASLF DTSVNFLVKP PSSDADDTFN LVSDEQPGLT
DYIKLEAQDS DLTSISLSST LDPKFAQQIL SGLASVVDAF FFDAEIPVSY LRLEAVLSST
SQKNPTLKPQ DTNSGFAHSL FEDMVSRFGD KTALEDEHGS AVSYTQLNQR ANQLANFLRS
RAILPEGIVP ICLDKSIDMV VAILGIFKTG AAFCALDPTS QPSRNQFILK KIGAKLIITD
PASSYSLECF RCEHVVLGQL DTFQFSCENV VVPTLSPESL AYVIFTSGSS GDPKGVLITH
NNAFNASKGM IKATGANDSW RSLWALNYIF DGSYFDLFAV LGSGGTLCLV SQSRVFSNLA
GFINQFDVTH VNVTPTIVNK LLIPSDVPNL KALVVGGEPL VPEILETWAP LLPVYNNYGP
TEGTILATTA LIEPTSTIND IGMALSTSIL SILEFDSKAP APLGELGELC LGGPQVARGY
LDNPDATHAA FFSQDDGSRI YRTGDVARQL SDGRFELFGR RDNQVKVNGY RIELGEIESA
ILRTGMVKTC VVLAAKVHSK TQLVAVCQLL SDFPDNIEEN ITPLLPPSEA HSFQDLQTRL
VTLPRYMIPA VWLPVAYLPL LPSGKTNRKE VLKLIESMED SLVASYQDPQ STSVNGEADH
SAPETDEERL LKTAWASIFG CNLHSFGTTS SFYSLGGDSI AAINLVSESR KLGYELSVAD
VLAFPSIKEQ ARVIKPLLAT NGSLPSSPHV YEVEDDIYDT LHRCGVDQED IETIYPCVPG
QAEFLTQGHT DHQFWQLQTV RRVPSDFDVQ RWIELVQKLT AKNTILRAMF IKSVKKNEPP
KWVQVILKEA VLDLETIRYD TLEERERIID ALWDGRFQVG KPFIQYRILR STMDGTLDLY
IKMDHAMYDG TLLRIFDDQF IAMAKNEEPP KPTEFTELIK YHSSSNTGKM LQFWVNLLGG
NKFDYPTQSL EPKAGGMVFR SFGTEVNDFA HGTGITVPIV FQTAWGLLLS YLSNSPDVTY
DNLLTGRNVN LDNPQLINGN CANFLPFRTR FQDTKTLRTL LHDTQVLFWE TTENGMVGLA
DIYKALGVDR SKRAAKTMFC FQPFDPPPKT LDAHMRWIVM GVSQNRMFFN YALMCEVFKS
PTGYKTKFQY DPKVIDESAA ERAADTFISI FDFILGCTEC TSVGNLYGKL KIDFGGGPAA
SSEGTEQIMD NRRCTEVE
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