ID   C6HE87_AJECH            Unreviewed;      1138 AA.
AC   C6HE87;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Exonuclease II Exo2 {ECO:0000313|EMBL:EER41108.1};
GN   ORFNames=HCDG_04754 {ECO:0000313|EMBL:EER41108.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER41108.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG692424; EER41108.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HE87; -.
DR   STRING; 544712.C6HE87; -.
DR   VEuPathDB; FungiDB:HCDG_04754; -.
DR   eggNOG; KOG2045; Eukaryota.
DR   HOGENOM; CLU_001581_1_2_1; -.
DR   OMA; VASWPWF; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.40.50.12390; -; 2.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR014722; Rib_uL2_dom2.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   PANTHER; PTHR12341:SF83; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:EER41108.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          275..679
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          728..915
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          919..1133
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   REGION          455..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1138 AA;  130395 MW;  F30D8A4C31E7157C CRC64;
     MGVPKFFRWM SERYPAISQL IAENRIPEFD CLYLDMNGII HNCTHKDSDS PTFRMTEDKM
     FIAIFNYIEH LYGKIKPKQL FFMAIDGVAP RAKMNQQRAR RFRTALDAEL AKEKAIKQGI
     EMPKEEAFDS NCITPGTEFM AKLTQQLKYF INKKVSEDVE WQGVEIVLSG HEVPGEGEHK
     IMEYIRQSKA QPGYQPDIRH CLYGLDADLI MLGLLSHDPH FCLLREEVTF GRQSQKKSKE
     LEHQNFYLMH LCMVREYLEL EFQELEEENA LQFPFDLERV IDDFILMAFF VGNDFLPNLP
     NLHINEGALA WMFKVYKQVL PKLGGYINEQ GTINLERLGV LLDSLSDVEF RFFEAEFSDA
     RWIKSKMKGE ELESSEPPAN AKDFAISPAQ KHIFSRIKKY VTHRPVNDQG QSVPLDLSPN
     LPARDRKFVE QLADDLHLAW TTVSNEHGDR FLRVQLPSKE TQTSGSAGDD DGDDEEGQIA
     LLRVMKRYEN AKVKETTAEE AQQAAEKKYE LKFQEWKDNY YKSKFGWAMD NHEEMRQLTE
     NYVQGLQWVL YYYYRGVASW PWFYQYHYSP MISDVKLGLE ADMNFDLGQP FHPFEQLMGV
     LPDRSKQIVP SAYHELMTSP ESPIIDFYPR DFELDMNGKK MEWEAVVKIP FIDEKRLLSA
     MATKKHLLTP EENARNEFGV TLKFTYSPDI EYIYPSSLAG VFPDIAKCHC IENVFDLPTM
     EGLEPFVGLV EGVKLGHEAL AGFPSLKTLP HNGQLGFHGV SVFQQESRNE SMVVTLSEPE
     NRSSVELAKQ KLGQRVHVGY PFLQEAKVTR VSDELFDYMH VDGEQHVVSI PHTPSQTDQW
     RRKAHQVESY YSKRLGMVVG EIESMVHVQM LKGLMKTAEG ASVKEFADIP GIETDYALQL
     VVDRVMCEDD RFIEREALPV EEEFPEGTRA FFLGEYNYGA PVHITGHEAG KLSGLVSVTK
     GREPEFGRDL TRAAEKLSPY SPSFAIARSL NLNPLALAKI TSSFTVVLDG QRINLGLNLK
     FEAKKLKVLG YSRRGPTGWE FSEKAIDLLQ QYMIKFPEFI AGIQRKPQGD GFQATDFYPA
     ETAAAKIKEI QAWLKSIEAK NFDRVPLEAE QLDSNLVKSI EQAADDSSVH DQQLKLKA
//