ID   C6HEA9_AJECH            Unreviewed;       516 AA.
AC   C6HEA9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Cat eye syndrome critical region protein {ECO:0000313|EMBL:EER41130.1};
GN   ORFNames=HCDG_04776 {ECO:0000313|EMBL:EER41130.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER41130.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; GG692424; EER41130.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HEA9; -.
DR   STRING; 544712.C6HEA9; -.
DR   VEuPathDB; FungiDB:HCDG_04776; -.
DR   eggNOG; KOG1097; Eukaryota.
DR   HOGENOM; CLU_022829_2_0_1; -.
DR   OMA; LYKYRPT; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409:SF37; A_DEAMINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          354..491
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   516 AA;  59130 MW;  6A895CFFEC40CD26 CRC64;
     MDNEQEKRRR RIGNLQHIED LTPRKINKKM VKFRWAQASF SNREESQSDK QSATGSSTSI
     AQSLIARYNG ARDKLWKQEL ELAFDAGAVD QAPKIENDAA SVVQAIRDEE RSRYLKAGAS
     DHFLANVDLI NRGSDLMRVA RELPKGAHLH CHFNTVLHPS FLVAQARHVK CMFIRSTRSL
     NVNDNLNDAA ITFSVLQDST EGADIFDPNY EPLAWMRYSK FLEDFPGGRE QAEEWLVKKL
     LISLEDAHAI DQNLEEVWDL FNRRTQMMKG LFNYESAFRN YIGKAIHSFV EDNIMYAEVR
     PNFFDKYIVS DDGERQLDHR FDMVGCEGRG NQIRDYLPLL LQFRATCTNL GLDIPFIFHA
     GETLESQGPT DNNLYDAILL DSKRIGHGFA IPQHPLLMQM CRERGIALEI CPISNEILHL
     CPSMKNHVLP ILLANAVPCT INSDNPAYFN SSLSHDFYQI ILHIDSITLH GCRILAEWSI
     EHSCMDPKQQ ADAFNTWEAD WTAFCQWIVL EFGPKY
//