ID   C6HEI9_AJECH            Unreviewed;       383 AA.
AC   C6HEI9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Aminoglycoside phosphotransferase domain-containing protein {ECO:0000259|Pfam:PF01636};
GN   ORFNames=HCDG_04856 {ECO:0000313|EMBL:EER41210.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER41210.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000256|ARBA:ARBA00006219}.
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DR   EMBL; GG692424; EER41210.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HEI9; -.
DR   STRING; 544712.C6HEI9; -.
DR   VEuPathDB; FungiDB:HCDG_04856; -.
DR   eggNOG; ENOG502SMG7; Eukaryota.
DR   HOGENOM; CLU_021768_10_2_1; -.
DR   OMA; VRCTNCL; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR21310; AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED; 1.
DR   PANTHER; PTHR21310:SF55; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          158..349
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  43405 MW;  5A5B2768D4048685 CRC64;
     MSKRKRLEEH GDAGSKQSKA ARFNIHTLKR LQKAVAADPE IDLTSDFPKD YSKRLSEMRI
     PLPSPTITTI TAATTSGSDT EEDIRVFLMP SEPTAIIFPL ADSVRSLLAD ADMSEALVGL
     MRRCEILWKS PFPRKKMVFK CDGNIVIKAI KNALDYTEYT TLQYLEVHKP TVPAPRPSGL
     LRMNDVSLIF MTYTSTTTLA DIWAWLDISQ KKSIQDQLNQ ILTDLRSLAN PSGTSLGGVC
     GEGCKDVRRH LRRSTEPILT VKDFKDFLFP SLRASIFAEF ISRLQQPYVP PQQLEIRCVF
     THGDLRPDNI TVEPSGDRQF RITGLLDWEY SGFYPEYHEL IKSTNGLGPS ADDDWYLFLP
     KCISLESYGM WWVLDYAQGA FME
//