ID   C6HEM3_AJECH            Unreviewed;       490 AA.
AC   C6HEM3;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   13-SEP-2023, entry version 50.
DE   RecName: Full=SGT1 and CS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HCDG_04890 {ECO:0000313|EMBL:EER41244.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER41244.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the SGT1 family.
CC       {ECO:0000256|ARBA:ARBA00008509}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692424; EER41244.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HEM3; -.
DR   STRING; 544712.C6HEM3; -.
DR   VEuPathDB; FungiDB:HCDG_04890; -.
DR   eggNOG; KOG1309; Eukaryota.
DR   HOGENOM; CLU_039532_3_1_1; -.
DR   OMA; KSGPKNW; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR   CDD; cd06466; p23_CS_SGT1_like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR007699; SGS_dom.
DR   InterPro; IPR044563; Sgt1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR45862; PROTEIN SGT1 HOMOLOG; 1.
DR   PANTHER; PTHR45862:SF1; PROTEIN SGT1 HOMOLOG; 1.
DR   Pfam; PF04969; CS; 1.
DR   Pfam; PF05002; SGS; 1.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS51048; SGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          238..329
FT                   /note="CS"
FT                   /evidence="ECO:0000259|PROSITE:PS51203"
FT   DOMAIN          371..490
FT                   /note="SGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51048"
FT   REGION          197..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..430
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  53209 MW;  CAFDFEAA912887DD CRC64;
     MDEAQRGAKA LAASNFPAAI EHYTRALIVN PHATDYYIKR STAYSRLRTE DGGSNGQAAL
     RDAEIAVALG LQRARREQIL AGQMRRAISL FQLGRYGDAD FVFKLVRGKV GPSAVNTMES
     AMVANSGSAT SATATSKELD IWELKVGNWM RKLEKDDERL RVTVQEFPGI RVPEEAKLKE
     IFRKQLEENV GMAVGNTGAE KKSVNNGKNV SALGNTAPEG SQRTSTAPPG ANPQAPVVTN
     VRHEWYQTHD TVVVTLYAKG VPKEKADIDI QEDSVSVAFP MASGSDFSFN LEPLFSLVDS
     TASKATVMST KIEIILRKKQ PGQKWGALEA TSTSQPATTS SKGNSSPTIP PATKVSPQPS
     TTTPSTDHTP SYPTSSRNGP KDWDKVASSL TKKSKKKESK GKEKEESSTS ADRDAKEEVD
     DEDEGVESDT SEYGTGDPVD AFFKKLYAKA DPDTRRAMVK SYYESEGTAL STNWSEVRKG
     KVEVKPPSDD
//