ID   C6HGP4_AJECH            Unreviewed;       376 AA.
AC   C6HGP4;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Plasma membrane iron permease {ECO:0000313|EMBL:EER40546.1};
GN   ORFNames=HCDG_05135 {ECO:0000313|EMBL:EER40546.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER40546.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC       9.A.10.1) family. {ECO:0000256|ARBA:ARBA00008333}.
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DR   EMBL; GG692426; EER40546.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HGP4; -.
DR   STRING; 544712.C6HGP4; -.
DR   VEuPathDB; FungiDB:HCDG_05135; -.
DR   HOGENOM; CLU_046738_1_1_1; -.
DR   OMA; CCNPLTD; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004923; FTR1/Fip1/EfeU.
DR   PANTHER; PTHR31632; IRON TRANSPORTER FTH1; 1.
DR   PANTHER; PTHR31632:SF2; PLASMA MEMBRANE IRON PERMEASE; 1.
DR   Pfam; PF03239; FTR1; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW   Iron {ECO:0000256|ARBA:ARBA00022496};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022496}.
FT   TRANSMEM        6..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        292..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   376 AA;  41999 MW;  0E41562022529821 CRC64;
     MVNVFAVQIF FIVFRECLEA VIIVSVLLSF LKQCLGQPHQ DPTIYKRLRK QVWLGSIVGV
     IFCLIIGGVF IGIFYGLGDD IWSSSEDLWE GIFYLIATII ITIMGLALLR INKSKQKWRV
     KIAKALMERN KGSSRWARGD WGRRYAMFIL PFVTTMREGV EAVVFVGGVS LGYPATAFPL
     PVITGIITGL LTGWLIYRGG NVMSIQIFLI ASTCVLYLIA AGMFSKAIWS LQYHVFAVKV
     GSDVAEVGSG PGSYNVKEAV WHVNCCNPKT DSGWDVFNAI LGWQNTGTYG SVISYCAYWI
     LIIACISWMM YEERTGSVPL AHRFWSVVAL IPLLRSFAKK KLETMDAKQQ DIVRMVNSAM
     FLESTAAETS KATQRE
//