ID   C6HIU2_AJECH            Unreviewed;       742 AA.
AC   C6HIU2;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Formin GTPase-binding domain-containing protein {ECO:0000259|SMART:SM01140};
GN   ORFNames=HCDG_05976 {ECO:0000313|EMBL:EER39754.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER39754.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG692428; EER39754.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HIU2; -.
DR   VEuPathDB; FungiDB:HCDG_05976; -.
DR   eggNOG; ENOG502RXE8; Eukaryota.
DR   HOGENOM; CLU_008022_0_0_1; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR010473; GTPase-bd.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          245..503
FT                   /note="Formin GTPase-binding"
FT                   /evidence="ECO:0000259|SMART:SM01140"
FT   REGION          1..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          690..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        251..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  82619 MW;  881B4723C6FC0C7F CRC64;
     MSPAMQNSGI FVDEQSGHSK TSGLRSIFPS KAHKRNHSAG SALIGNALPN DHTSMPPPML
     PLDHPHSYTQ WPLSEVSHNG HQPSNARLRN KSSEANSDYS LHKKTKSSVS LRSLMKDFTT
     PNKTPSPEIT VREKKAKKTK SSTSLSAIFR RSQRGRRDNT SNKQQKDKEN MNPPHSPTVE
     ISPLYSHFGS TSQQQVQGGN RYLPERGRTL DEEMSLYTPR GYSPSKQRNF HGHQLPFLTK
     RSDTKPRPKS EFVLPTSSSM KDMLASVQRS GASNEQQWQK AGDSRANHDQ NTSSGSANGG
     KDSSGKGSRS QSRTRPFSIS RADILSPKRS NENMTTHKRP KSVDLSRPGS SKGLPSSNSM
     TGIASQAQPD HTADPTDFVH YLREVQKPEI IEVGKLHKLR ILLRNETVTW VDAFISHGGM
     NEIIELLYRI LKVEWREEHE DALLHETLLC LKALCTTSLA LRHLSSVESV LFPTLLHMLF
     DEEKKGPSEF TTRGIVLSLL FTHLSSASAE NLVPRAKTIM AYMRDPTPPE ESQPLNFIAS
     IYQPRPYRVW CKEISNVTKE VFWIFLHQLN VVPVTKATEI NSEPYSKRYF PPPRPPVPAA
     PYVGGVEWDA TNYIANHLDL LNGLLAALPT ASERNTLRTE LRASGFEKVM GTSLRTCKEK
     FYSSVHDSLK LWVAAAAEDG WDYKFVREGP ARGGPDSTSR SPIKSTPGSP KKRVGLVSDE
     PPKLDLTGEI GHEASETSSG WL
//