ID C6HL44_AJECH Unreviewed; 495 AA.
AC C6HL44;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Hemolysin-III family protein {ECO:0000313|EMBL:EER38981.1};
GN ORFNames=HCDG_06925 {ECO:0000313|EMBL:EER38981.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER38981.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG692430; EER38981.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HL44; -.
DR STRING; 544712.C6HL44; -.
DR VEuPathDB; FungiDB:HCDG_06925; -.
DR HOGENOM; CLU_042934_0_0_1; -.
DR OMA; WANRIRM; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR040976; Pkinase_fungal.
DR PANTHER; PTHR20855:SF142; ADIPOR-LIKE RECEPTOR IZH2-RELATED; 1.
DR PANTHER; PTHR20855; ADIPOR/PROGESTIN RECEPTOR-RELATED; 1.
DR Pfam; PF03006; HlyIII; 1.
DR Pfam; PF17667; Pkinase_fungal; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604254-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PIRSR:PIRSR604254-1}.
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 345..406
FT /note="Fungal-type protein kinase"
FT /evidence="ECO:0000259|Pfam:PF17667"
FT BINDING 124
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
FT BINDING 270
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
FT BINDING 274
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
SQ SEQUENCE 495 AA; 56146 MW; 4D6F470CAB5CAB6B CRC64;
MRDQSTATNT FQPLAAVEQP RTKYRLFTAT EVPLWYAHNS FLLTGYRPVT QSIRLCLESL
RYLHNETVNI YSHLVPAGIA VISNGVFHLY FRNRYPTASW AGQLAFHVYL CTSILCFGIS
SIYHTLLCHS EDYVKLWALL DYVAITFQTL GSFISGIYVS FYCEPGLQKL YWTMIGVLGL
LTATVVVSPR FQSSKWRKLR LSTFVATGFS ALAPMIHAAI IFPYAQWNQQ AGLGYYLLEG
LAIITGTIFY ATQFPESWMP ERFDIWGASH HIFHIFVALS AVIHVWTILN VFDYAPIMQS
RPLGRHSGAC RRGQDKLSKS GYGSLYFGQM LISGLAESTR PQRPPTRRFG LASALYRTKF
KAWVFNRSAS HSSDILEVHK DSEKFIQMIV GYAMMSYEEL GLDVIRTHLS GLYIPWSLRG
GKTRGVGWLA QGQKAAQRCT PSIVSMLLHM RDCTNTGQNL VIQEHQVLWA NRIRMALCKP
TFGILDPRQI VVDEQ
//
