ID   C6HNH9_AJECH            Unreviewed;       905 AA.
AC   C6HNH9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Importin beta-2 subunit {ECO:0000313|EMBL:EER38025.1};
GN   ORFNames=HCDG_07760 {ECO:0000313|EMBL:EER38025.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER38025.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   EMBL; GG692432; EER38025.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HNH9; -.
DR   STRING; 544712.C6HNH9; -.
DR   VEuPathDB; FungiDB:HCDG_07760; -.
DR   eggNOG; KOG2023; Eukaryota.
DR   HOGENOM; CLU_008136_1_0_1; -.
DR   OMA; AQEGAMS; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          305..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  100959 MW;  FDD76218E0920FD9 CRC64;
     MLVQATTSPD FANYLTYLFS TPQPPSHIGF DLHTYNVIRI AAALNLKTKL RVAYGTVTPE
     SLEYIRSSAL SVLQDPSPPI RNSAGSIIAE IVARGGLLAW PNLLDELLSL VSNSSGSVPM
     LTQEAAMSAL SKVCEDNKKL LDKDFQGQRP LDIILPRVMQ CTSNPSPRIR STALATIHMF
     LSQRPNILIG SLDTFLGHVF QLASDPNTDV RRMVCQSFVQ LVDIAPDNLI PHLGGLVDYV
     LMQQHDPEDP ELALDAAEFW LAIGEQKKLH EPLVPYLSKI IPILLRSMIY DEDDAILLAG
     EHDDAETEDK VEDLKPQFAK TKSSRLQLTG GDDKPNGDVN EAGADDDDLS EGEIEDDLYE
     YGDDDPEAEW TLRKCSAAAL DVFANVYHQP VFEIILPYLK DNLRHAQWTN REAAVLALGA
     IADGCMDTVT PHLPELIPYL ISLLSDPEPI VRKITCWCLG RYSEWAAHLD AAEKTQFFEP
     MMEGILHRML DNNKKVQEAA ASAFTSLEMK SDANLLPYCQ PILRQFVLCF EKYKDRNMYV
     LYDCVQTLAE SVMSELAKPE LVDILMPALI QRWNKLSDQS RELFALLECL GYVAAAYGDA
     FSPFAPPIFA RCVKIIYTNI QDYLTAVNHN TGEEPDKDFL VTSLDMLGSI IQAIDPQKSS
     ELVTTSQPPF FELLRFCLED SNWEVRMSSY ALLGDCAINI FPTLAPVLPT IMQILIKQLD
     LNLIRDDESE NGLRVINNAC WASGEIVAAS KDGMAPFLEN LFQALTAIMS NEEVPDSVNE
     NAAMALGRLG IGCAQQLAPH LGEFADMFLR SMTKIDFTRE KASSFFGFNQ VVRENPKAME
     SCLSDYFHAI AVFPRKSLNQ PHFEDLQQSF QQVLQGYKDL IPDFNSFMAS LPPAISRKLQ
     TAYQL
//