ID C6HRT2_AJECH Unreviewed; 672 AA.
AC C6HRT2;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cyclin {ECO:0000313|EMBL:EER37216.1};
GN ORFNames=HCDG_08667 {ECO:0000313|EMBL:EER37216.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER37216.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; GG692436; EER37216.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HRT2; -.
DR STRING; 544712.C6HRT2; -.
DR VEuPathDB; FungiDB:HCDG_08667; -.
DR eggNOG; KOG0834; Eukaryota.
DR HOGENOM; CLU_022000_7_2_1; -.
DR OMA; TAYYMAT; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20545; CYCLIN_SpCG1C-like_rpt1; 1.
DR CDD; cd20546; CYCLIN_SpCG1C_ScCTK2-like_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF51; CYCLIN-K; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 62..168
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 181..268
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 283..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..510
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 75729 MW; B3E38DDC2EC71204 CRC64;
MPATTSSSTR EPAHSVLMPS NPVLVAAQSQ WIFTDAELYR TPSVLDGMAI EAEHTSRSKG
VNFITQVGIL LKLPQLTLCT ASVYLHRFFM RYSMKDLPQR PGMHPYSVAA TALFLATKVE
ENCRKMKELI VACCRIAQKK PSMIVDEQSK EFWRWRDTIL HNEDLLLEAL CFDLQLEQPY
RLLYDFLCYF KVQENKRLRN SAWAFLNDST YTVLCVQFPA RTIAAAALYA AARHCEVAFE
DDSLNRPWWR QLDVDLHEMR RACNRMADIY EFVSVPVPGQ QYVHLSTRDD EPTDMTRTSY
HPKSEGSIDD SANNSMSPGE INGRKRERDS HSGSFSQHPI SIPPNGATSG EPDPQPSPKR
QRREGSEGDT ETSSFSQPQQ PSSSQISLTE ATANMNVASN SSSQTAISIP SSQKQPEMNG
HGHPRNVSPS KSRIPQAARI PLNQPRQEHP LPPPPPVTVP PLPHQQPQPP RRGSYSNNPQ
PPNRQPPPRG PPPATVSSMF HLPPPPADPS NVDKLQQRID AIIQQGMPQE NDRSHEPRGN
YYYHPSSSER DRDRDRDRHR ERDRYRDNDR DKDMARERGR DHDRDHGIDH HGRSRRHSSE
TSGPGAMSTS LPTLPPQQSV APPVPSSEPR HDLEQDQQIK RDVVGTNTAS LQDHDTKTNE
ADDDGGSEEG EL
//
