ID C6HS74_AJECH Unreviewed; 849 AA.
AC C6HS74;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DUF221 domain-containing protein {ECO:0000313|EMBL:EER36892.1};
GN ORFNames=HCDG_09055 {ECO:0000313|EMBL:EER36892.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER36892.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GG692437; EER36892.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HS74; -.
DR STRING; 544712.C6HS74; -.
DR VEuPathDB; FungiDB:HCDG_09055; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OMA; PKRYYAH; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..190
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 213..407
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 419..626
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 751..841
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 95807 MW; 5400C9AACAA327D5 CRC64;
MADFLNPNND PNIGSSRGDN QSTVDSTLNS LGVDVSTSAT ALLTTFVPAF ILFTLWTLVF
IICRRSQQRF YAPRSYLGNI HEHERSPELP SGWINWIGAF FNLSDTYVLQ HSSLDGYFFL
RFLRLMSVTC FVGCLVVWPI LFPIHATGGA GNTQLDALSF SNVTDPNRYY AHVLVAWMFF
SFIFYMVTRE GMFYATLRQA YFLSPLYASR ISSRTVLFMA VPKALLTGSK MTKVFGKSIR
RIWITTDCKK LDELVQRRDK LALRLERLET DLIKSANLAR SKAMKRQKND EECAADDGVR
PKTTGCDFDS VPWANKVKRP THRLRYFIGK KVDSIEWLRS ELEKVLPEVE KLQKKHRDGG
AKPIPAVFIE FDSQAAAQTA YQMLSHHQPF QMTPRYIGIT PQQIIWPALQ YSWWSRIVRK
FLAQAAITAL IIFWSIPSAF VGMISNVAYL SNLLPFLSFI NKLPQVIQGV ISGLLPAVGL
ALLMSLVPVL LRFLARQTGL PTTVHVELFT QNAHFCFQVV QVFLVTTLTS AASAATSQII
KDPMSVKDLL AKNLPKASNF YISYFLLQGL VLSAGAVVQV VGFLIFKIFV AFFDTTPRKL
YERWTSMNGL RWATVFPVFT NMVVIAHISL NDALRPLLSA LPRTLEQAER LGDGDDDDNN
KDMGEQDDSA SSCQDDATSE KSPISPASGS NEIPSPISTS SKLKRATQTT ITLAEITRAG
TSTEIPAFPH RKPSALQTIL RKFSYFIHSI VQPHIYIDYS TLRKRIRQGT PIEYSDEVAD
NAYYPPSVWS PTPLLWVPRD AGGISRREVE LTSRVTPMTD EEAHLDERNK VKWDEVKSQP
PIWQEKVFY
//
