ID C6HSC6_AJECH Unreviewed; 1159 AA.
AC C6HSC6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=DNA excision repair protein Rad2 {ECO:0000313|EMBL:EER36944.1};
GN ORFNames=HCDG_09107 {ECO:0000313|EMBL:EER36944.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER36944.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR EMBL; GG692437; EER36944.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HSC6; -.
DR STRING; 544712.C6HSC6; -.
DR VEuPathDB; FungiDB:HCDG_09107; -.
DR eggNOG; KOG2520; Eukaryota.
DR HOGENOM; CLU_003018_0_0_1; -.
DR OMA; PNSMDFS; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 1..98
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 836..905
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 579..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 792..819
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 590..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1159 AA; 131747 MW; A614F218C45BF8D9 CRC64;
MGVTGLWTVV KPCARPIKIE TLNRKRLAVD ASIWIYQFLK AVRDKEGNAL RNAHIVGFFQ
RICKLLYFGI KPVFVFDGGA PTLKRQTIMS RKQRREGKRE NAARTAGKIL AVQIQRKAEE
EIETQRRMRA NSLEPEEPLP DHFVYVDELN MTPEERQKNR QFRKQDAYHL PELDVSLAEM
GAPNDPRIMS HEELEEYARQ FHSGEDISLY DFSKIDFNSP FFVNLPPSDR YNILNAARLR
SRLRMGYSKE QLDNMFPDRM AFSRFQIERV KERNDLTQRL MHLSGMTDDD SLYEIGSNSR
IAGERGKEYV LVKNSGVEGG WALGVLGNKD EGQRNKPIDV EEYGEHLLSD DHNALENEDE
DFEDVPIEGL NRMPKLPVFD RGVFDKKFGE HSRKVTDHRT KEVVDKSLDQ TNSGKYTLFV
PEEPSRSTVD HDTLHKYSRF QDTSDNDDLL RAIQMSLETG NDQAVLQLDV SSSSDKNQEI
SKVAIGEEDV SDIADDEDMN FFAALSKSKA MNIKPNAPIS NPFDGPLPFE PLKIRKPTSW
DKVIDVTGPS EEPTSNGQRI PQALPPWFDV KLTEKTLLNQ DPGNEVDGVD PTSDARRCDN
TPKEGEMINF DVGVARGIEI NELETAGRDN QAHRVPIQSN ASNCRTCHPP VSSREPLANT
FSSTQEHTEP EGTAEQEADN RGSVENNGEA YEWETTYHKD VQNEKSNSKM KTQEAILPPS
PDFEDAKIYC PSEALQTSPH MYNSSDDTSR HNNFTHYDHD SDDFSDPEDD ELIHQLQKEA
EEHARFASTL NSKSQAENAF NYEQELKQLR SQQKKARRDA DEVSHIMVSE CQELLRLFGL
PYITAPMEAE AQCAELLSLG LVDGVVTDDS DIFLFGGTRV YKNMFNQAKF VECYISNDLE
KEYNLDRNKL IQFAHLLGSD YTEGIPGVGP VSALEILTEF PTLEDFRDWW SQVQMGAKLP
EDSHSIFRKK FKKNVTKLFL PPGFPDKRVD TAYLEPKVDS DPSAFQWGVP DLNALRQFLM
STIGWSQERT DEVLVPVIRD MNRREQEGTQ SNITNFFQGP QGAGAFAPHR RPDGKSRMQK
AFSRLRHQAQ MKQRGSGPVP DEDKAPNPSG SKHSTNRKSG KRSPDNGYPT SNDREITGDN
KSDTAHKTSK KQKTTKRQR
//
