ID C6HTL3_AJECH Unreviewed; 202 AA.
AC C6HTL3;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 03-MAY-2023, entry version 38.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430};
GN ORFNames=HCDG_12011 {ECO:0000313|EMBL:EER36347.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OG Mitochondrion {ECO:0000313|EMBL:EER36347.1}.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER36347.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU004430}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|RuleBase:RU004430};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU004430}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC {ECO:0000256|RuleBase:RU004430}.
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DR EMBL; GG692467; EER36347.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HTL3; -.
DR STRING; 544712.C6HTL3; -.
DR VEuPathDB; FungiDB:HCDG_12011; -.
DR HOGENOM; CLU_085957_1_0_1; -.
DR OMA; DQINSIG; -.
DR Proteomes; UP000002624; Mitochondrion.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR PANTHER; PTHR33269; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR PANTHER; PTHR33269:SF17; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU004430};
KW Membrane {ECO:0000256|RuleBase:RU004430};
KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:EER36347.1};
KW NAD {ECO:0000256|RuleBase:RU004430};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Respiratory chain {ECO:0000256|RuleBase:RU004430};
KW Translocase {ECO:0000256|RuleBase:RU004430};
KW Transmembrane {ECO:0000256|RuleBase:RU004430};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004430};
KW Transport {ECO:0000256|RuleBase:RU004430};
KW Ubiquinone {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:EER36347.1}.
FT TRANSMEM 16..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 98..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 175..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
SQ SEQUENCE 202 AA; 23472 MW; 756A6718957EBB29 CRC64;
MFFFSDYINN GYRDEFLDII YIICIFFSLY TIISKNPVVS IFFLIGLFLS ISCYLFFIGL
EFIGLSYLLV YVGAVSILFI FILMLINIRI SELLSETYNY IPLAMLSVIL FIYILGQNIP
NNISVLGYNK FENLKQEYFF NYKENIQYVI SLNWDNSLVN NTQISSIGNV LYTNYSIWLL
IISIILLLAM VGTIVITLNK NK
//