ID C6KST9_PLAF7 Unreviewed; 465 AA.
AC C6KST9;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Citrate synthase-like protein, putative {ECO:0000313|EMBL:CAG25334.1};
DE EC=2.3.3.1 {ECO:0000313|EMBL:CAG25334.1};
GN ORFNames=PF3D7_0609200 {ECO:0000313|EMBL:CAG25334.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAG25334.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAG25334.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566}.
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DR EMBL; AL844505; CAG25334.1; -; Genomic_DNA.
DR RefSeq; XP_966082.1; XM_960989.1.
DR AlphaFoldDB; C6KST9; -.
DR SMR; C6KST9; -.
DR STRING; 36329.C6KST9; -.
DR SwissPalm; C6KST9; -.
DR PaxDb; 5833-PFF0455w; -.
DR EnsemblProtists; CAG25334; CAG25334; PF3D7_0609200.
DR GeneID; 3885935; -.
DR KEGG; pfa:PF3D7_0609200; -.
DR VEuPathDB; PlasmoDB:PF3D7_0609200; -.
DR HOGENOM; CLU_620387_0_0_1; -.
DR InParanoid; C6KST9; -.
DR OMA; FFIMRLL; -.
DR OrthoDB; 261994at2759; -.
DR PhylomeDB; C6KST9; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 2.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CAG25334.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transferase {ECO:0000313|EMBL:CAG25334.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 401..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 465 AA; 56204 MW; F5D1FF2A199269B5 CRC64;
MINLKSKMCK LLLMGHRKVP FFHFVKNDFL KNDIKCFCNN SKNKKYEKIK KEKKHIDDTT
SLFLETEIFF EHKDIFYRGI NIVDLCSYGN FEETIYLFLY KKLPNIKELK EKRNIFINAL
NLLDEKRIFE MYNNVSHCNI LELLRNYFIH SSQDKKKISD INTCYYEILA SYLKLINPKY
SLENYKNVFL DHKIYTNDFV SSCLLFNFYI KSNCLKEKIK KEKNDKIVMN NIYNYDHINN
HIESKDVICK VPQVNYDMYS IKLISNVLII LCDNNINEST FLIRMISNMC TNYFNICISM
VTFYIDIFKE INLHTSLQYF LNFKMFQNKK ENKDIINDNI EENQLNFFFL KNNNFNKKNN
ILKKIITDYC KVTSQHNINI LNHFIQVENY FLKHKNKYPS LYYYTLLLFH ILNIPLYYYP
SFYFISRLLS FTAHINEQKE NNKIIKYAGV YMGIPARQYV HIEKR
//
