ID C6KTB6_PLAF7 Unreviewed; 173 AA.
AC C6KTB6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=6-pyruvoyltetrahydropterin synthase {ECO:0000256|ARBA:ARBA00013100};
DE EC=4.2.3.12 {ECO:0000256|ARBA:ARBA00013100};
GN ORFNames=PF3D7_0628000 {ECO:0000313|EMBL:CAG25093.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAG25093.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAG25093.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0007829|PDB:1Y13}
RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ZINC.
RG Structural Genomics of Pathogenic Protozoa Consortium (SGPP);
RA Bosch J., Hol W.G.J.;
RT "Structural Analysis of Plasmodium falciparum 6-pyruvoyl tetrahydropterin
RT synthase (PTPS).";
RL Submitted (NOV-2004) to the PDB data bank.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis;
CC tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005126}.
CC -!- SIMILARITY: Belongs to the PTPS family.
CC {ECO:0000256|ARBA:ARBA00009164}.
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DR EMBL; AL844505; CAG25093.1; -; Genomic_DNA.
DR RefSeq; XP_966263.1; XM_961170.1.
DR PDB; 1Y13; X-ray; 2.20 A; A/B/C=1-173.
DR PDBsum; 1Y13; -.
DR AlphaFoldDB; C6KTB6; -.
DR SMR; C6KTB6; -.
DR STRING; 36329.C6KTB6; -.
DR PaxDb; 5833-PFF1360w; -.
DR EnsemblProtists; CAG25093; CAG25093; PF3D7_0628000.
DR GeneID; 3885700; -.
DR KEGG; pfa:PF3D7_0628000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0628000; -.
DR HOGENOM; CLU_111016_3_0_1; -.
DR InParanoid; C6KTB6; -.
DR OMA; CAHFIAF; -.
DR OrthoDB; 48098at2759; -.
DR PhylomeDB; C6KTB6; -.
DR BioCyc; MetaCyc:MONOMER-20101; -.
DR BRENDA; 4.2.3.12; 4889.
DR Reactome; R-PFA-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR UniPathway; UPA00849; UER00819.
DR EvolutionaryTrace; C6KTB6; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0003874; F:6-pyruvoyltetrahydropterin synthase activity; ISS:GeneDB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; ISS:GeneDB.
DR Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR InterPro; IPR007115; 6-PTP_synth/QueD.
DR InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR PANTHER; PTHR12589:SF7; 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR Pfam; PF01242; PTPS; 1.
DR SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:1Y13};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CAG25093.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0007829|PDB:1Y13};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0007829|PDB:1Y13}.
FT BINDING 29
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:1Y13"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:1Y13"
FT BINDING 41
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:1Y13"
FT BINDING 43
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:1Y13"
FT BINDING 161
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:1Y13"
SQ SEQUENCE 173 AA; 20061 MW; 795EC2CCE9E2D67D CRC64;
MMKEETLNSD NSSAEVSVES PSFSFNCAHF IAYNGFRETL HGHNYNVSLK VRGYVRDDGY
VIDFSILKEK VKKVCNKLDH HFILPIYSDV LKFENVKNNI KIICEDNSEY SFPERDCIKL
PIKHSSTEEI GQYILNQLIE EMDVSLLKSR HIHYIEISVS ESPTQKAIVH KYI
//
