GenomeNet

Database: UniProt
Entry: C6KTD2
LinkDB: C6KTD2
Original site: C6KTD2 
ID   SET1_PLAF7              Reviewed;        6753 AA.
AC   C6KTD2;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   05-DEC-2018, entry version 64.
DE   RecName: Full=Putative histone-lysine N-methyltransferase 1;
DE            Short=PfSET1;
DE            EC=2.1.1.43;
GN   Name=SET1; ORFNames=PFF1440w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T.,
RA   James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A.,
RA   Kyes S., Chan M.-S., Nene V., Shallom S.J., Suh B., Peterson J.,
RA   Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W.,
RA   Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S.,
RA   Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M.,
RA   Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C.,
RA   Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000312|EMBL:CAG25109.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000305}
RP   SYNTHESIS OF 3412-3441, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-
RT   helical coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
RN   [4]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=18299133; DOI=10.1016/j.ijpara.2008.01.002;
RA   Cui L., Fan Q., Cui L., Miao J.;
RT   "Histone lysine methyltransferases and demethylases in Plasmodium
RT   falciparum.";
RL   Int. J. Parasitol. 38:1083-1097(2008).
CC   -!- FUNCTION: Probable histone methyltransferase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC   -!- DEVELOPMENTAL STAGE: constitutive pattern of expression.
CC       {ECO:0000269|PubMed:18299133}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine
CC       as determined by epitope response in sera.
CC       {ECO:0000269|PubMed:17653272}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AL844505; CAG25109.2; -; Genomic_DNA.
DR   RefSeq; XP_966279.2; XM_961186.2.
DR   ProteinModelPortal; C6KTD2; -.
DR   SMR; C6KTD2; -.
DR   BioGrid; 1210423; 12.
DR   PRIDE; C6KTD2; -.
DR   EnsemblProtists; CAG25109; CAG25109; PF3D7_0629700.
DR   GeneDB; PF3D7_0629700.1:pep; -.
DR   GeneID; 3885750; -.
DR   KEGG; pfa:PF3D7_0629700; -.
DR   EuPathDB; PlasmoDB:PF3D7_0629700; -.
DR   InParanoid; C6KTD2; -.
DR   OMA; CCESIYN; -.
DR   Proteomes; UP000001450; Chromosome 6.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019904; F:protein domain specific binding; ISS:GeneDB.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   1: Evidence at protein level;
KW   Bromodomain; Chromatin regulator; Complete proteome; Merozoite;
KW   Metal-binding; Methyltransferase; Reference proteome; Repeat;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase; Zinc; Zinc-finger.
FT   CHAIN         1   6753       Putative histone-lysine N-
FT                                methyltransferase 1.
FT                                /FTId=PRO_0000388753.
FT   DOMAIN     1832   1902       Bromo. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00035}.
FT   DOMAIN     6612   6729       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN     6737   6753       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   ZN_FING    1671   1728       PHD-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
FT   ZN_FING    1761   1819       PHD-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
FT   ZN_FING    1764   1817       RING-type; degenerate. {ECO:0000255}.
FT   ZN_FING    2510   2579       PHD-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
FT   ZN_FING    5496   5532       C2HC pre-PHD-type; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01146}.
FT   ZN_FING    5558   5610       PHD-type 4; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01146}.
FT   COMPBIAS     66   6329       Asn-rich. {ECO:0000255}.
FT   COMPBIAS    451    575       Lys-rich. {ECO:0000255}.
FT   COMPBIAS    843   1091       Lys-rich. {ECO:0000255}.
FT   COMPBIAS   1460   1591       Lys-rich. {ECO:0000255}.
FT   COMPBIAS   4196   4338       Lys-rich. {ECO:0000255}.
FT   COMPBIAS   5401   5520       Lys-rich. {ECO:0000255}.
SQ   SEQUENCE   6753 AA;  796045 MW;  EF689CABCFA20F00 CRC64;
     MSENSDEGKM QKGKGNEMNE DKIICKKEES NSSSYKFISF IKTIEDVKEK WKSSNLSRMD
     VLKLKNDDIN NDDNMNNMDN MNNMNNMNNI NNMNNMNNIN NMNNMNNINN MNNMNNMNNM
     DNMNNNEKHP CSNNNYSFNN YIKESINYNT CTGYDKNNIM LNFLDKHKKS IFLKSRNNVN
     TFQSDINSSK TSSFFSCMSL KNMNYHNDIN KYSNYRMMKN INGLHKLMIL KNKNKDKKLF
     TNTSDKKNYY CLNNGDHIIN EKDSFSDTYI SYGCRKRRWK KKKKNIYNML FYDESINDYP
     YKNLEKTTFS NSSKIYELFF NKYKKKKILN IECSGNKYKG LLRTNHFPPY ANFNFTIRRK
     LQTSNVLGHF MISKCNFNRT ICYRKYIKCV NKYKNNKRNR VINMYVKKEN VDSIKGTFGN
     MNNGVHHNNS RRRLNNTSKN NISNNNNNML KKKKGKKNYK GSFDQMIQED TTLDQAKKES
     IKTVSKNERK NNMNKHSHDN KVSKLNKRMS NKRRNNKNCN PSNDMCNEDD VIEKICTTEE
     VNDDEKKKKL SRHKKFVCER KKGVILQNNN KCKKKNDDNI INNNNDDVNN CGDNINDHHD
     NRKDYDTTED QNKCPKILSI NFIKCDEKLF EKIYNDMFLR IGKIVTNKRK KYFLIYKIVK
     DSFFRILILN TEKLEKNILQ VMAVQDVILC DKNVKIYSDP IYIRNNNKLY AIKFLKIFSL
     KYMKKVKNMS EVNFSDDDEC KKENKDNISE SSKRSNNIGE KKMLHVEKSE EHDDMTSDSN
     KEDTKIEEGR KKSNEVNIDV DDGEEEENVN NNDNNNDNNN DNDNSSDNNN NDDGSNDTES
     CSKINKSKYK GKEKKDVKEN TDDKNLSDSN SNNSKKKFKV LNKAIKKDND KKKKYEKKNI
     EGNSNNNMIL VRSNSSSTST SNSSSKSKSS NCRNKKNNQI SICSKMDEKN SEQKKKNIKK
     KNKTCNEGKS KKDSTKLNCV KKVKNKSTDK KNGKSKINIK NEKKKKINNS KINKGRKGIN
     KKDKGKGDDN NYVCLIYDDE KKFYFNFKKF KDIINVIKGS DESTRFYVDT NNNNHNNNMK
     KKMKLFKKVE KSLYLENLDI DTDEILFRRP KFFNCIIEES FENYDINYEG EDGNFYVFKN
     KLNKIRKKVT IKNETDSSDM YIELKDEEKG FKYIGYRVSF ELKKDNKKKA QVKVGIIKYY
     SPKYKQFFIH HLENYKLYQT SDLSKGNNNN NNNNMKENGF VKCGRNSYSR ACSKSLNSSI
     YINKYKNVEL NEKITNIIDD DNNNNINSSC IYKNNLSNEN NLCADKVLCD GNYNMLENDV
     DEMNNVDQNQ KKRNDLVFSD VKGWYSPYFY NIKILNNYKE FERFDILEKC DKKKEMTDHV
     NNTLNKNEIC SICSKRILFM KGHDHYSCSL SSAIYDMCSE AEKKEIDENN CIDIYWGIKC
     FTCEKKYHAN CLEDDVLITK WFDKNILMKE YKKFIYKNSL KKEKRYFNNN GKNKRTKNGK
     KKKNTIHKLE DKNNSHVVST ASNSHSIEVS SSESAKKGNE KNTATCKKRK TSCSALYKKV
     KKGKNKNGEN KNGENKNGDI KNDDIKNDDI KNDDIRNDDD KNDENEENTK ECKNESNNID
     NNNSSNDSLS DVDNNKDNGK SKNKKYRRCI NYIPSVEHSD ITYKKFICKD CYRCIYCCES
     IYDYKQTPNV ANYVICKNCN MVAHGSCCFP NVPDIYLFNW KCDDCLKCNK CNYSNLCYIN
     YNEWELHLDC CINCYKEYEK KNFCIMCNEK YDEDDSKKWV QCDVCKFWIH LSCDKNESRN
     IETLSNKNID YKCPTCSIGT FHDKIERILY LLFLLDKYKN FTFHVPINYS IYWRIVKIPM
     NLYIMKKKIW EKKYDTILDF LYDFMLIIHN AKMVHMPNTP IYKNACIFEK KGRVIIKNMF
     NMTNEYLNKC IEDCVENYKN EINNLDSFQI GHDNNNNNDN NINNNNKMEG VNNESVIFMN
     DGCNNKLYNK EGTNMTCVNM DSINKNLNDM NNNNNNNNKM EVFCGQNNIK LNEYYINKEG
     YNIISNDNNM NYDNYNNVQN IGMKKMYTNI NDYNSSNVPN ESVYNKENFI NNSSIYNINE
     NNTYDLNCDK KLIFDNKYNL SAYQNEGDIM NYNGMYQKNI NISNPPYNNN NNNNNNMVKE
     GEKYILNNDD MNNISISKDN DINNNCNNIA NIYRKRKLEQ YKKDITQYEL YELFDFKNDS
     FFINRNKEMF SCSSNDHNLI DYNILYVKLN GKIYFNTFYD KHDEFDVCKI LKVHFLKNNR
     RGGGNHIMCP KIRNNQNLKE DVTQCDEEKI EQNNDNGCDD EYDNNNNNNN NIGSSSISSI
     NKIHMNDTYN NSINDNSLRH NNNCSVFINS NIFMIDVLNE KVKINNIVKE TKRIISPINN
     VLKFLKCIQI VFFYDNNTNE CTEKEKNVIS SNLCNNNFEK YVNINSIDHN NMSGEKKRKS
     VEEIMSVVDN KSYYGFNKCS EYILYSSNEY DRAKKKENKR IKLLKNDILK ECCYICGSIE
     YKNNFIYCCI CGISVHYSCA NIVHPFLFNL NDYKDHKKEI NNILNIITRN FKCDNCIKCD
     NCLLHFDSSL KHNLYFKLKN LNVSCNNNRM ERRTYNYLYD VKIKVFTTNK EGTKQTGKCV
     MKTKENDIIK LDEDNKQKDE LNEANKECFY KQDDVHVEKN CDELLYKNSF NSEECNKNEK
     KKNDNNVDEN DDNVDKNDDN NNNNNNGDDN NNIDNTLVDG DMNKLENDLN NSNDFSINEE
     KKNNKDTKKY MISSKEEINK EIENVSNQMD NKNNDVDKKK NISNEEIILD NTKNSCHDND
     SNVLYNESVK KSFNACKIEK KEGIEKDDNL GHVNKLRNKR LIKILSIREE GNKLVKCFCC
     GKPSHDECFY IIDNNTYKNK ICTLKKTVKN YVRKKNVENK CNTKVEMNSD VILLDDNIKD
     HCSVNKTGDE HMNNNEFIDI SKDKISEHNI LDESFNSGVV CSDKNRKDQV VFIDGDVKNN
     DISIIEENVT YYTSKEVNNN SVLKNERDVE STSELYIGGD KHVYNKLETD NAEMESNNNN
     NNNNNNSDCN NNVSTLSTAA VNTINRSHMS PQKNDNDMNK INQDDIIHTK MNDKKNVKDD
     NGNMTNLNNN IDKNDRNLDT ILKEHSVIMQ KLDELKENRN KEHDGEFYNN LILNNQFLIH
     SFKVEEGVEI NKDSIIINKK MFNKYILNKI YELLDNKKRV RIKDLFNLFN LDEFRCSFIL
     YEVLNALNTY LNEKLKEYNL TKIRNGTYKK YENEIRNENF CLFNKYLIVN NRDKINITKV
     VLKIQSLITE ILSDAMNGNI VDEKDKSKKK ESISSDFNVV NNVKEYNIQN GCINIDINNY
     FKGEYINFKP ILCSSQFNLD TNAQIFLQNK ANLSMFQKSA SYNNNFENNL ENNFVNNKMN
     NMNNMKNNMN NMNNIMNNIM NNNMNNIMNN IMNNNMNNII NNNNIFNNDV SNNVDMQHKS
     DQICIFNSNN IHSVPIFNNK PYMDNNFNNM VLVNKSNDIN GDDILCNMKN LYNKSVCNKQ
     EKNGYSVVHK NICDVNFPYN DTKIWNGDIT NKSKTYTYTN INNNGSVIDY RKWSSVNRSV
     SMNNMNCIRS NTNPRILSGT DHILKNNHMN KRNNVNNTYG VNNVNNVNNV NNTNNVSCFM
     MRRKIRSNSL HDMNDKMNKM NDNINININN LNIINNNINI CNMNYPIDRV DSMNNTFNRN
     NIIISQNTKE NTNILNFNGN DFCNNNNNNN NIINKENNFG TSNFNSPFHV GNLAKSYSYN
     NTMSEKNMNE VICPNVRNNM SNMNNMNNMN NMNNMNNMNN MNNMNNMDSI NNVISYSCTN
     PNMKDINFNS MRRSSSTPKK STGLLKNYFN IDIDQYNKTN SHIMNYNVSI NNDMNNVYIN
     NNNNHNNNNN NSCNNFINND VINMNNVGTF YNFNQNAESY NNISNNIKCS NINNIIINNN
     MNVNNLNYFC NNKEVGFKEN DLNINQKVHT INKDPYEMNH SKMYVTFPYC NTKDNNSNKS
     SLKSNVLRLD KIRNRNIKKP LLYNRSSSMH SSDNLIYNVH NNNRNSPAEF TSDIIINKER
     NMENNYNTSI NYVNNNITNN IIVANNNCYH TANNFIQINY SPSSSNIVNI NKDSYKYDIS
     LENCIDLGST NTCMYNLNNI HNKDINNMPL EDCFSHIGSC PNEQNEHEDE INEDNKKDVT
     KQQKKRKLNS VSKKDMLIKK EMNADDNINC KENTLQNESP KKDDELREND LKTTTENIKS
     NEVEDKEFVD KKKKRKLSVK VKVNVNVKVE LQDTENDENK EKGIKKEKND EEKKNDAEKK
     KKENKKGREK SVKVRKTKNQ TQVERENEKE NLMENVTNDK TSDIINNKTS DIINNKTSDI
     INNKTSDIIN NKTSDIINNK TSDIINNKTS DIINDKTNDI INNKTSDCLS LVQNNKPVIH
     IDCNTSLDIT DGYNNLISCE GRKKGKYNIE ENNINDDNMF QYSDAFDSEG SIKYKEEYDK
     IYIPNNKNKI NNINNFLIKN NLLLKSKFMR ITPNTYLCRN CVLLYQNDFS YNTYEEEINK
     MERSILNEYE KGVIKKNEYV HDAIQNDKVV NTDENIMTNV LADKVDDMKI VEKLNCPLNV
     EEKGIEENIL YVKREGDELI NYGKHNDQMK EEEESEVVLG DVDFLKNEKK DNLILPYDEK
     YTGVNNNNSS IIMSLKKCDK NITKKKGKDK NFNNIKYFKI DNNKSLWYEN YMYWMNKISL
     YNNLFFTNMY YKENVIKCID MNNLFLNKMN IYKCSICCML YHCSNMDRNN FFIKNEDKMR
     KKTKKNDCLK LLYICNLCTI KYDYVLKIIT YKENNKCWNE FYTDNYYKNN FYELVYFIIK
     IIYKNIYINN FFNIFCSIMD NIFKEHKTLN MKLLSLFLFS NKYFKYEEFY HFFNNKMKKD
     DRVFKKTFHM KNVCFMPRYS KKSIMYYIFS LFCNKIYNIN KKKKCIHNKR SYIHNKQSYI
     HNKRTDVMYD NNVYFHLYEL ARKKLYDYSE KSQKPFDEII NMCLYLLYLY YLCNVLYKCV
     RINNVLKGDK DKGDILCDNK KMKYYKKRKN IKLFLNIINS NEYINVNKIF HGKCIYELPF
     YVNKERIKKK RNSVREFINN NDNNQENNAD KKKDHHIYNQ NYNHNSYLCD IGKVDESLHS
     KEDNKKDVII TNNASIDSTS PSINMNKSVV SSIYSYNSNK EKKKNMRKCI KGLHHTIKNK
     LNLYVKLMLD KYIQESSNYI KNENKDIKKT IESKNKDDKI CLLCNFSNYI YKGRLIPFYD
     IYIHSECLKW SLNCTQCCYE ENKNKTIVNN DNGTKVDVNL DNADDIINNN NMNMLDNNMN
     GPIKNNEENN NNNDNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     KSKKNTQKKK DHVNDVKINQ NNSNNKNNKK KKTSKDNEEL KSDNTKNNKT KDSDGNNNDK
     TKLEKINLIH NKQSNEISCK IDNNNIINDI STNNPYMKEK KCKNKEKNRG SKNNNIKNIK
     LIDMCEWKED RNFYNIYENM IEVDEDNVKE IIFDSIKSTC FLCGYNNASV YCSNEDCNVK
     FHLNCAFYST VIKDPSNNPF FRYLKCFNLV EFNKDTIFYK NMYHDPNVNN SVSSHVCTDN
     RYYKEMIEKN YVDIFPVHII YKIKKIWCNK CWNKKKIYNL FYIQKCFMSP YYYDNIKTEE
     SVPNKITPMK KDKSDITNEV KEEKDDDILY DSKVHKEYFT LRNILMDDNL LNNIIRNKKS
     CSMEIQENND KMKGDNNIDN EDVRNVLCDG EERVSYNRNK LNDILLKMDM KDILKYFIDF
     YFENGSYYIL DNILYSVNHC VKIKYKKKSL YNIQDVLNKE TKIGTMMREL EGLISKYVNR
     SNDNNYMDRK YDMLLLKNIK SDINNDNNND INNNDNNNNE NNNENINDNN NNNNNNNNNN
     NNNNSNNNNN NNYYYYHNNE GKYNEQGSYQ HIDIQNIIND KSVENLIKGY FILKNFLHIG
     NNNITLQNED LLILKKSENS FVHNLYDNDK VYNVHVPYVY TKKMNTSYMN KKENDKKYNK
     SVNKNSCKSK NSILDNINFD KNKNKITKKY TAFIIDNNEY TTDCSNEENN TSDDEENENR
     KNENDDDNIP EHIKMNNIMN SQQKKENDFK NINLYFQLTN VIKKVSINKL EGNFFNYEEK
     GNLLGSNVSK IKMNELLECN VGEENFCDDD QKFSDNKNYA SDDEEKKKKK RKNQTRFYNY
     PKRISTTNNN KNVNVLVNSL NNNLINKKEY FLNIIMNENN DLYMKKINEK YFPNYHPKKR
     KKKKLDNTSY INHNYNYNYP YNYNLLSNNS KSRILKVGCH NILNIGDILK YDGDKIIYPC
     GYLNMRIFYN LPSYYLFQIY KNANIDDINR KTKLLEKIFL QLRATYIFSI TLREQNFFFS
     ILLFPLINID YFSESDATNF ILAEGYNINE VYMKFLSLFN SQNYICDDMN NDYSHYNAKY
     GNIYKCLETY ILKSVEHNKF IDSHTFFGLT LPCVVYQIKY KLFKYMYKHL SEKIKTYIKK
     SKDSVMKKRI KGCTREVVYN DNVLCKYSNL DTTIFKENEK ENEKNIRKTV KYKYNINSAM
     SYRYLMNISS NLRLYVKKSS IHGYGLYTCE FINEGEPVIE YIGEYIRNII SDKREKYYDK
     IESSCYMFRL NENIIIDATK WGNVSRFINH SCEPNCFCKI VSCDQNLKHI VIFAKRDIAA
     HEEITYDYQF GVESEGKKLI CLCGSSTCLG RMN
//
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