ID   C6PYL3_9CLOT            Unreviewed;       888 AA.
AC   C6PYL3;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Penicillin-binding protein transpeptidase {ECO:0000313|EMBL:EET85646.1};
GN   ORFNames=CcarbDRAFT_3880 {ECO:0000313|EMBL:EET85646.1};
OS   Clostridium carboxidivorans P7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=536227 {ECO:0000313|EMBL:EET85646.1, ECO:0000313|Proteomes:UP000004198};
RN   [1] {ECO:0000313|EMBL:EET85646.1, ECO:0000313|Proteomes:UP000004198}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P7 {ECO:0000313|EMBL:EET85646.1,
RC   ECO:0000313|Proteomes:UP000004198};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Larimer F., Land M.L., Hauser L., Hemme C.L.;
RT   "The draft genome of Clostridium carboxidivorans P7.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EET85646.1}.
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DR   EMBL; ACVI01000081; EET85646.1; -; Genomic_DNA.
DR   RefSeq; WP_007062765.1; NZ_CP011803.1.
DR   AlphaFoldDB; C6PYL3; -.
DR   STRING; 536227.Ccar_15990; -.
DR   KEGG; cck:Ccar_15990; -.
DR   PATRIC; fig|536227.13.peg.3352; -.
DR   eggNOG; COG0768; Bacteria.
DR   OrthoDB; 9757901at2; -.
DR   Proteomes; UP000004198; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004198};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..324
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          377..590
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   DOMAIN          721..859
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   888 AA;  98254 MW;  27D75448D8F02D2D CRC64;
     MEGKKERKFT RYTALIVIMV IIFTAIAGRL FFLQILDGES YSEKANNKSI REIPEAAPRG
     KILDKNGSIL ASSNLIYILA YNQTDESDKH FFDTMSKVFD VLDKNGETQK DDFELKVNPY
     SFQFRGDDDK TKRMLEIKFK TDRGFADEIK NKLYKNKKDK LTEAEKAKVD EELLKITPEE
     TFKKLVKQYK IDDKKYSVDE QRRFMIIKDT LKMNSFSGYK PAVVATNIKK ETAFKFYQML
     NEFPGIDVTT QPMRTYENGE LASDVLGYIS KIDSNDDKYT EKGYDASTDY VGKSGIEGTF
     EDRLKGSKGG KIVKLNKQGR ILEELGKRDP YPGQTIQLTI DKDVQAATEK ALDDRMKYLR
     ANPAEQQGSY TANATRGAAV AIDVNTGAVV ALASRPGFDP NAFAAPGGLS SDLYNTYYPD
     IAEAGKRYIE NMGISGGSEE DTLNKLFPVD KSVKGKTVRQ DAKDILPKPL FNYATQSRSM
     PGSTFKMMTA IAGLESGVIT PDFGVDDEMY FDKGGGKAGR VYFTNDGPNG WVDLARAIEK
     SSNPYFMTVG KMLRNAYGDD ILAKYAWKFG LGADPTSNSK KSTGLEIPEA FGQVFNSWSL
     KNTYSQTYLW TTMEKLKAGS DDRGNNFTSI DLYDRDGDSS KVKSIKSDIK KQIQSAIKDG
     DKAFNKDTYK SLINNLVQED PQYKDKNVSD KEMKSIINAI YYVAVSDANS QIRAGFSMYD
     ASIGQGINAF TPVQIANYIA TIANGGTRYS VHLVDKFLDA NGKLIEQVKP EVAEKTGVKQ
     ETLDAVKAGM NAVNEKGTAA EAFKGFTIPT AGKTGTATIA NDQESFGRTD TAVYVGFAPS
     DKPQIAVCVM LYDGGHGSGA AYVARSMYES YFKVGSSNTS KTDTSAQN
//