ID   C6Q0H9_9CLOT            Unreviewed;       392 AA.
AC   C6Q0H9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00044137};
DE            EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
DE   AltName: Full=Acetoacetyl-CoA thiolase {ECO:0000256|ARBA:ARBA00030755};
GN   ORFNames=Ccar_0530 {ECO:0000313|EMBL:ADO12109.1}, CcarbDRAFT_4546
GN   {ECO:0000313|EMBL:EET85014.1};
OS   Clostridium carboxidivorans P7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=536227 {ECO:0000313|EMBL:EET85014.1, ECO:0000313|Proteomes:UP000004198};
RN   [1] {ECO:0000313|EMBL:EET85014.1, ECO:0000313|Proteomes:UP000004198}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P7 {ECO:0000313|EMBL:EET85014.1,
RC   ECO:0000313|Proteomes:UP000004198};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Larimer F., Land M.L., Hauser L., Hemme C.L.;
RT   "The draft genome of Clostridium carboxidivorans P7.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADO12109.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P7 {ECO:0000313|EMBL:ADO12109.1};
RX   PubMed=20885952; DOI=10.1371/journal.pone.0013033;
RA   Bruant G., Levesque M.-J., Peter C., Guiot S.R., Masson L.;
RT   "Genomic analysis of carbon monoxide utilization and butanol production by
RT   Clostridium carboxidivorans strain P7T.";
RL   PLoS ONE 5:e13033-e13033(2010).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; HM590564; ADO12109.1; -; Genomic_DNA.
DR   EMBL; ACVI01000115; EET85014.1; -; Genomic_DNA.
DR   RefSeq; WP_007063431.1; NZ_GG770679.1.
DR   AlphaFoldDB; C6Q0H9; -.
DR   STRING; 536227.Ccar_22790; -.
DR   KEGG; cck:Ccar_22790; -.
DR   PATRIC; fig|536227.13.peg.4714; -.
DR   eggNOG; COG0183; Bacteria.
DR   OrthoDB; 9764892at2; -.
DR   Proteomes; UP000004198; Unassembled WGS sequence.
DR   GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:EET85014.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004198};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EET85014.1}.
FT   DOMAIN          4..261
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          269..391
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        88
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        348
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        378
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   392 AA;  41191 MW;  FE232060317B7801 CRC64;
     MRDVVIVSAV RTAIGKFGGA LKDVTTVDLG ATVIKEAVKR AGIKPEQVGE VLMGCVYQAG
     LGQNAARQAS VNAGIPVEVP AMTLNILCGS GLRSISLAAQ IIKAGDEDII VAGGMDNMSR
     TPYVLQSGRW GQRMGASELQ DSMLHDGLHC AFNHYHMGVT AENIAEQWKL TREEQDAFSV
     ESQNKAEAAI KAGKFKDEIV PVVIKTRKGD VIFDTDEGPR PGTTMEALAK LKPAFKKGGT
     VTAGNSSGIN DAAAALVIMS ADKAKELGLK PMAKIVSYGT KGLDPSIMGY GPFYSTKLAL
     ERAGMTVDDL DLIEANEAFA AQSLAVARDL KFDMSKVNVN GGAVALGHPV GCSGARILTT
     LLYEMQKRGS KKGLATLCIG GGMGTSVIVE RC
//