ID C6WIH2_ACTMD Unreviewed; 555 AA.
AC C6WIH2;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACU36215.1};
GN OrderedLocusNames=Amir_2275 {ECO:0000313|EMBL:ACU36215.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU36215.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU36215.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP001630; ACU36215.1; -; Genomic_DNA.
DR AlphaFoldDB; C6WIH2; -.
DR STRING; 446462.Amir_2275; -.
DR KEGG; ami:Amir_2275; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_59_10_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACU36215.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT DOMAIN 42..398
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 449..526
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 528..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 61190 MW; 4503A895493040F0 CRC64;
MDFRQARDFL LQHADDHDAA RAGFAWPDLA EFNWALDWFD EIARDNDRTA LWIVEEDGSE
GRWSFAELSR RSAQVANWLR GNGVARGDRV VLMLGNQVQL WETLLGAMKL GAVVIPATTL
LGPEDLRDRI ERGGARHVVV TSGDAPKFAE VPGDYTRIAV GAPVDGWLDF ADSERADAAF
TPDAPTRADD TLLLYFTSGT TAAPKLVEHT HVSYPVGHLS TMYWQGLRPG DVHLNISSPG
WAKHAWSNVF APWNAEATVF VHNYRRFDAA RLMAEMDRCG VTSFCAPPTV WRMLIQADLT
ALRVPPRKAV GAGEPLNPEV IEQVAKAWGV TVRDGFGQTE TTVQIANTPG QPVKPGSMGR
PAPGYEVVLV DPITGEPGTE GEICLDLSRR PLGLMVGYHG DPERTAEVMR GGYYHTGDVA
SVDEDGHLTY VGRTDDLFKS SDYRISPFEL ESVLLEHDAV AEAAVVPSPD PVRLAVPKAH
VVLAPGWEPT AETALAVLRH ARERLAPYKR VRRLEFGPLP KTISGKIRRV ELREQEDGGR
PDGEHREEDF PQLRG
//
