ID C6WJN0_ACTMD Unreviewed; 680 AA.
AC C6WJN0;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Flagellar biosynthesis protein FlhA {ECO:0000313|EMBL:ACU36255.1};
GN OrderedLocusNames=Amir_2315 {ECO:0000313|EMBL:ACU36255.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU36255.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU36255.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835}.
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DR EMBL; CP001630; ACU36255.1; -; Genomic_DNA.
DR AlphaFoldDB; C6WJN0; -.
DR STRING; 446462.Amir_2315; -.
DR KEGG; ami:Amir_2315; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_11; -.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000313|EMBL:ACU36255.1};
KW Cilium {ECO:0000313|EMBL:ACU36255.1};
KW Flagellum {ECO:0000313|EMBL:ACU36255.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 680 AA; 72102 MW; 558983CB41D553F5 CRC64;
MNAKRLNQFA VPAGVILIIV MMILPVPSFV LDLLIVANIA LSLLIVLVSM QVKRPLEFSV
FPSVLLLATL FRLALNIAAT RLVLLDGDAG AVIGAFGHFV VGGSLIVGMV VFFILIIIQF
VVITNGAGRV AEVGARFTLD AMPGKQMAID ADLNAGLIDE AEARKRRTEV TSEADFYGAM
DGASKFVKGD AIAAVIITLV NLFGGFAIGM IQRGMEAGEA INTYSLLSVG DGLVSQVPAL
LLSLATGIIV TRPVSDGDMG SQVFSQFGRN RLVPMVAGSA LLCLSLIPEL PMLPFLLIGG
GLLFLGMRMP KQDEEGGEAV AVPEQAAPDA SEALLSEMQV DPLELALATD LVELVDSSGG
DLLERVRALR RKIALELGVV MPPVRTRDDL DLPLSTYVIR ISGSDVATGT APAGAVLAIG
DNLDSLPGRP GVEPVFGLAG KWVPAELRYQ AELTGATVVD RASVIVTHLA EVTRTQASRL
LGREDVRQLT DVVRRTHPVV VEELTPNLLS LGEIQRVLHR LLDEDVAIRD LVRIYESLSL
AAKSGSTDTD HLVEAARNAL GPAIASRFAS GGVLSVMTLD PRVEQVLLES LRMTEHGAQV
VLDPNLAEQL VGDVSRLALQ TEERGATPLL ACAPQLRAPL YRLLHVAVPR LAVLSYPELS
GGTNRIETVG VVNSVHSIAA
//
