ID C6WLD7_ACTMD Unreviewed; 1691 AA.
AC C6WLD7;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ACU38330.1};
GN OrderedLocusNames=Amir_4486 {ECO:0000313|EMBL:ACU38330.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU38330.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU38330.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP001630; ACU38330.1; -; Genomic_DNA.
DR RefSeq; WP_015803217.1; NC_013093.1.
DR STRING; 446462.Amir_4486; -.
DR KEGG; ami:Amir_4486; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_241165_0_0_11; -.
DR OrthoDB; 2378856at2; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT DOMAIN 537..613
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1592..1667
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 512..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1674..1691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1691 AA; 180774 MW; 7F34D847101EAA56 CRC64;
MVDSAAQARR ELLRLMLSAA PEPPAPTRPA GGLPTSAAQR RLWFLDQLNG PNSAYNVPFA
LRLRGPLVPD ALWGALDDLV ARHEVLRTDL VADEDDEVRQ EVRPPAPLPR AVETVAGEDV
EARIAREAAR PFRLDGEPLL RALLLRVADD EHHLVLNLHH VVTDGWSETV LFRELGVLYS
ARALGRAADL PPAAQYADYA VWEAGQAGGP VFEAQLAHWR DRLSGHLGEA GIPTDRPRPL
RASTLGANVP VPAPADLRAR LRSSLGGASL FTGVLTALAV LLHRYGGRDR VVVGVPVINR
TREDWESALG FFANTVALRL DLSDNPSLGA VADRVTAETL DALSHQHVPF DRVVDALDAH
REAGMNPVFQ VMCSVNEVTA PPELVGLEPT LRSLDNDTAK FDVEFAVEFS GDHVDCRFEY
ATDLFDRPTV EALARHYRLV LDALLADPST RVGDLVLATE AEATAVLDGE PVVLRDRYGA
PVPVGVPGRA GDRTARLRRD GVVELLAEPD SAGAHGSAAL DGDGPDGGGP AAGVLAEPVT
PTERALAAIW EEVLGLARVG RDQHFFRGGG GDSMLATKVV VRVRRLWSVR VTVRQMLQHP
VLSDLAAHID SLAPRALPQA PAVEPGPVAD TPLSHAQQRL WFLEQLEPGG SAYTIAELLD
VTGPLRADAL ERALNAVVAR HDALRTTVAE VDGVPLQRVA PSVVVALPVV DHTSPERALR
EAWRQADRPF DLAAGPLVRA TLHRVGPERH LLALSWHHLV FDGWSQDLFL RELGAFYARE
TGADVPVPPA PAVQYADYAR WQRASLRDAE LTRLHDYWSA ALADAPTLLE LPTDRPRPAT
RGTAGSSRDL LLDAELARGL RDVARHHGVT PYLVLFAAFN ALLARHTGSE DLVVGGTTAN
RDTPEVEGVI GLFVNTLALR TDLSGNPAFG ELTARVRDTV TGAYAHQELP FEQVVELLRV
ERSPSRTPLF QVLFDYQENS WSELELPGLE VRRARGEDSS AMFDLTLVVI AGPDGLHCDL
QYATDLFDEG TALRLLARWE ALLRSVVRTP DARLHELELL PPDERALVTG TWCSPRAVDR
APGLVPERVA AVPPDATALV RGARSMTYGE LNDRAARLAA RLAGLGVGRG DRVLVCAPRG
FDYVVASLAA MRAGAAYLPL DAATPAARVA HVVARSTPKA VLVTPGTRGL VEHPAVLEIG
ADHGVPPAPI VPVGPGDAAY VIHTSGSTGT PKGVQLDHGG LAHRVDWYTA DCGLTARDRV
SQIAGTAFDV SVLEIWTALS AGARLHLADD DTTASGEHAV RWLAEHRVTV AFLPTPLCEL
ALDLPWPEDS PLRVLTTGGA ALRKRPRPDA PFTLLNLYGP AEATVVAVSA AITPDGPRVP
PIGVPVPGAR ALVLDRHLNP VGVGVPGDLH LGGVGVANGY VGRPDLTADR FGPDPLGGGD
RLYRTGDLAR WLPDGTLEYL GRLDDQVQLR GFRVEPGEIA AVLLAHPDVA DAVVVAREEP
GVGTFLVAYV VPAAGPDGAG PDGAGPDGAG PDGAGAMPEA ANALRAHLAT QLPDYMVPTT
TVFLPELPLN RSGKVDRAAL PVPTRGGVDH VPPRDDLEAA VAGIWRELLR VDRVGVHDDF
FALGGHSLLA TKVVSRIRSE LSVSLPVRQL FETGTVARLA AVLADARAEP GAGEPAVVRR
ERRLHRPPVN P
//
