ID C6WRU3_ACTMD Unreviewed; 443 AA.
AC C6WRU3;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Sodium/calcium exchanger membrane region {ECO:0000313|EMBL:ACU36935.1};
GN OrderedLocusNames=Amir_3015 {ECO:0000313|EMBL:ACU36935.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU36935.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU36935.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001630; ACU36935.1; -; Genomic_DNA.
DR AlphaFoldDB; C6WRU3; -.
DR STRING; 446462.Amir_3015; -.
DR KEGG; ami:Amir_3015; -.
DR eggNOG; COG0530; Bacteria.
DR HOGENOM; CLU_050651_0_0_11; -.
DR OrthoDB; 57558at2; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..215
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 245..390
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 443 AA; 46523 MW; B0E95DBAA7CA42F5 CRC64;
MTLSGDRGTF PRRLPVAAAF ALPGALLGAA DYLGLPHPDL PPPIAAAIFG IAIVAAAFLL
SWAAEAAQVD VSAGLAIAVL AMVAVLPEYA VDMVFTFEAG QVYAEHGTCA GQGGANPCSL
ALANMTGANR ILVGIGWPLV VLVAGLAVLR KGRERGQERP GSVRPGRVEL TPVMSAEVVF
LGVATLYSLT LPLRDSLTFF DAAVFVSIFA AYTWRLSKAP AEEPDLHGVS KWVGEQAKRR
RRGWVAGLFG FAGLVILACA EHFAQNLVDT GTTLGVDEFL LVQWVAPLAS EAPELIVACL
YAIRLAASES LGTLLSSKVN QWTLLVGTLP VVFAISSGGV DGLPLDEHQR LELLVTAAQS
LFAVSLLVDL GIGAAGAATL FGLFAVQFTT SLLLPAEANR VVVLVLSGLY ALLAAIRLVR
RRAELARLVR DGVTTPFSEL ARR
//
