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Database: UniProt
Entry: C6WS54_ACTMD
LinkDB: C6WS54_ACTMD
Original site: C6WS54_ACTMD 
ID   C6WS54_ACTMD            Unreviewed;       733 AA.
AC   C6WS54;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=DNA helicase {ECO:0000256|SAAS:SAAS00413339};
DE            EC=3.6.4.12 {ECO:0000256|SAAS:SAAS00413339};
GN   OrderedLocusNames=Amir_5052 {ECO:0000313|EMBL:ACU38874.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU
OS   3971).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU38874.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU38874.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971
RC   {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D.,
RA   Goodwin L., Pitluck S., Rohde M., Goker M., Pati A., Ivanova N.,
RA   Mavromatis K., Chen A., Palaniappan K., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Brettin T., Detter J.C., Han C., Chain P.,
RA   Tindall B.J., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
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DR   EMBL; CP001630; ACU38874.1; -; Genomic_DNA.
DR   STRING; 446462.Amir_5052; -.
DR   EnsemblBacteria; ACU38874; ACU38874; Amir_5052.
DR   KEGG; ami:Amir_5052; -.
DR   eggNOG; ENOG4105EEM; Bacteria.
DR   eggNOG; COG3973; LUCA.
DR   HOGENOM; HOG000242779; -.
DR   OMA; DWRANAA; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR018647; DUF2075.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF09848; DUF2075; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002213};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Helicase {ECO:0000256|SAAS:SAAS00745242, ECO:0000313|EMBL:ACU38874.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213}.
FT   DOMAIN      178    594       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   COILED        3     23       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   733 AA;  80840 MW;  8B46E047ABEC8F8F CRC64;
     MAARGYEEEL DAERAHVAEL YARLDAERAR VRTEYDNALM GNGGNSGSLV ERDTEVRSLG
     REVKRLDVAD NGLCFGRLDA ITGERSYIGR IGLYDKDDDY EPALLDWRAP AARPFYVATA
     ANPEGMRRRR QFHTRGRRIV DYTDEVLGRP GDQERGDAAL LAAVNAPRGE GMRDIVATIQ
     AEQDRIIRLA HDGVLVIEGG PGTGKTVVAL HRVAYLMYTQ RERMERHGVL VVGPNPAFLN
     HIGRVLPSLG ESDVVFTTTG GFVPGLVVTA EEQDPEAARV KGSLKFLEVL AAAVADRQTL
     PEEPLEVRMG GHDLLLGRDV VEWARQEARD SGLPHNEARS TFTEILTYVL TERAIARIGK
     GWLTRDNKDA WERTRRELLK ELADDDSFTA LVDRFWPRLT PASLLAGLYS SPERLRAAGA
     DVGLLLRERG NAWTVSDVPL LDELVDLLGR DRADDAAAEA ARDREAKFAE GVLGMLVERA
     DMMDDEDHLI ASDLVDASDL AERFEERDTR DLVERASADR DWTYRHVVVD EAQELSEMDW
     RVLMRRCPNR SFTVVGDLAQ RRSPAGADSW GAVLDRYVPG RWVYRELTVN YRTPAEIMAV
     AASVLAGFAP SVRPPESVRS CGVPPWARRV PPEQVAEAVA EFTRAEAGRE GTSVVIGPPD
     VPGAVAASET KGLEYDAVLV VEPERILADG DRGAAELYVA LTRATQRLGV LHTAPLPESL
     SGLVEVEDPL TAR
//
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