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Database: UniProt
Entry: C6WW29_METML
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Original site: C6WW29_METML 
ID   C6WW29_METML            Unreviewed;       592 AA.
AC   C6WW29;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   SubName: Full=Potassium efflux system protein {ECO:0000313|EMBL:ACT48128.1};
GN   OrderedLocusNames=Mmol_1222 {ECO:0000313|EMBL:ACT48128.1};
OS   Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylotenera.
OX   NCBI_TaxID=583345 {ECO:0000313|EMBL:ACT48128.1, ECO:0000313|Proteomes:UP000002742};
RN   [1] {ECO:0000313|Proteomes:UP000002742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLW8 / ATCC BAA-1282 / DSM 17540
RC   {ECO:0000313|Proteomes:UP000002742};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M.,
RA   Chistoserdova L.;
RT   "Complete sequence of Methylotenera mobilis JLW8.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACT48128.1, ECO:0000313|Proteomes:UP000002742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLW8 / ATCC BAA-1282 / DSM 17540
RC   {ECO:0000313|Proteomes:UP000002742};
RX   PubMed=21622745; DOI=10.1128/JB.00404-11;
RA   Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA   Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA   Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT   "Genomes of three methylotrophs from a single niche reveal the genetic
RT   and metabolic divergence of the methylophilaceae.";
RL   J. Bacteriol. 193:3757-3764(2011).
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2
CC       (CPA2) transporter (TC 2.A.37) family.
CC       {ECO:0000256|SAAS:SAAS00568668}.
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DR   EMBL; CP001672; ACT48128.1; -; Genomic_DNA.
DR   RefSeq; WP_015832163.1; NC_012968.1.
DR   STRING; 583345.Mmol_1222; -.
DR   EnsemblBacteria; ACT48128; ACT48128; Mmol_1222.
DR   KEGG; mmb:Mmol_1222; -.
DR   eggNOG; ENOG4105CKD; Bacteria.
DR   eggNOG; COG0475; LUCA.
DR   eggNOG; COG1226; LUCA.
DR   HOGENOM; HOG000179076; -.
DR   OMA; DVIFVRI; -.
DR   OrthoDB; 941006at2; -.
DR   BioCyc; MMOB583345:G1GFC-1259-MONOMER; -.
DR   Proteomes; UP000002742; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR004771; K/H_exchanger.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00932; 2a37; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|SAAS:SAAS00460756};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002742};
KW   Ion transport {ECO:0000256|SAAS:SAAS01092081};
KW   Membrane {ECO:0000256|SAAS:SAAS00460792, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00328229};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00328251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002742};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00460753,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00460739,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS01092095}.
FT   TRANSMEM      6     25       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     32     50       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     56     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     87    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    115    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    183    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    358    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      398    509       RCK N-terminal. {ECO:0000259|PROSITE:
FT                                PS51201}.
SQ   SEQUENCE   592 AA;  64380 MW;  8F5DEBF6CEC21430 CRC64;
     MGTSNFLIQT MIYLSSAILL VPIFKRLGLG SVLGYLIAGI LIGPYALKLI PDPEHVLHFA
     EFGVVLMLFL IGLELESQKV WELRKILLGL GGLQVVSTLG LIAIIAHMMH FSWPVAIVIG
     MGVTMSSTAI GLTALAEKKQ LSTHGGQASF ATLLFQDLSV IPLFMLLAFI APDSGQSSFD
     VWAVAKALAV IAAIIVASRT LLRSIMRIVA QTEIREIFVA FSLLLVIGVS LAMQSVGLSM
     ALGTFLAGVL LADSEYRYEL RLDIEPVKGL LLGLFFIAVG MSVDLSLLAN SPLMIFGLAL
     LVVLVKITIL LGLAYVFKYS LRDGLLYGAA LSQIGEFAFV IFGIAFTQNT IPREIYNVLN
     AIVAVSMLIT PILLLLYDRF LTLQCGERPK DNIEENNSVI IAGFGRFGQI VGRVLLAKGI
     AATLIDNDPN QVDLMRKFKW RCYYGDASRL DLLEEAGIAT AKLLVISVND PVAALHIGKL
     VRERWPTLAV VTRARSRTDA FDLLDIGLDP IRETFYSSLV AAKQALLALG ETPTSAAKII
     KHFERHDIEQ IESARTIKHD MNALLSMSEK GRQDLKDLLA LELGEAGKSS GN
//
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