ID C6WXB5_METML Unreviewed; 1087 AA.
AC C6WXB5;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor {ECO:0000313|EMBL:ACT48564.1};
GN OrderedLocusNames=Mmol_1660 {ECO:0000313|EMBL:ACT48564.1};
OS Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylotenera.
OX NCBI_TaxID=583345 {ECO:0000313|EMBL:ACT48564.1, ECO:0000313|Proteomes:UP000002742};
RN [1] {ECO:0000313|Proteomes:UP000002742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLW8 / ATCC BAA-1282 / DSM 17540
RC {ECO:0000313|Proteomes:UP000002742};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., LaButti K.M., Clum A., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.;
RT "Complete sequence of Methylotenera mobilis JLW8.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACT48564.1, ECO:0000313|Proteomes:UP000002742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLW8 / ATCC BAA-1282 / DSM 17540
RC {ECO:0000313|Proteomes:UP000002742};
RX PubMed=21622745; DOI=10.1128/JB.00404-11;
RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT "Genomes of three methylotrophs from a single niche uncover genetic and
RT metabolic divergence of Methylophilaceae.";
RL J. Bacteriol. 193:3757-3764(2011).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000256|ARBA:ARBA00029447}.
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DR EMBL; CP001672; ACT48564.1; -; Genomic_DNA.
DR AlphaFoldDB; C6WXB5; -.
DR STRING; 583345.Mmol_1660; -.
DR KEGG; mmb:Mmol_1660; -.
DR eggNOG; COG0840; Bacteria.
DR HOGENOM; CLU_000445_107_20_4; -.
DR OrthoDB; 9813966at2; -.
DR Proteomes; UP000002742; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd11386; MCP_signal; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.20.120.1530; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR003122; Tar_rcpt_lig-bd.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43531:SF14; METHYL-ACCEPTING CHEMOTAXIS PROTEIN I-RELATED; 1.
DR PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR Pfam; PF18947; HAMP_2; 3.
DR Pfam; PF00015; MCPsignal; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF02203; TarH; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00283; MA; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000002742};
KW Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..76
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 672..724
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 775..1004
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
FT COILED 794..828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 975..1013
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1087 AA; 118911 MW; 2143737436497154 CRC64;
MKTSITLTQI EREINESVSI VLKTDLEGKI TYVNRDFIEV TGFNEQELIG KKQSVIHHPE
MPKEILTDIW MTLQSKKPWI GVEQGLCQNG DHFWVYSCVT TVREHGKVVG YMSVSKKSTK
EQIEKAHAHY RAIKHEERWH TALLRKAKDF SNRITINNKI ACIFVMVALT TCMLGFNGIS
GIKESNHGLE SVYKNRVLPL KQLKVINDMF STNIVSTGQK LQRGIITSSE AAANVDQALQ
VLEKEWKEYL ASPHAESESA LATEIQPLFD TALESAVLLQ GIIRSDDIER LMTYNTSDVY
KAIDPLTESL NKLSSLHYTG VATEYEITQA NYIKHRNYAI AFVFVALMIC ALLGWNLNRS
IIPRLRAIGS NLRESAEEMN NKLVPRSEHR DELTDVVDAY HALKTRLDFD HKEAVSSIQR
IKATLDQASI AVTLSNRDNR LIYMNHAAKT LFENMSAGIQ QYHPEFALDK MMGENLNQYV
ENAADRELLA AEISSAKTID TTMANHHLQL VVSPVYDETD GYALGQMTQW SNRTTEVIAE
KNVAKLIQQA VAGNLSERID TSTLPTGVIR DISSGINQLL DAIITPLTMA ANYVDHLSKG
VIPAEITDNY HGDFNIIKNN LNACGLAIKA LVADANLLAK DAEAGALTTR ADASKHLGEY
RKVIEGLNAT LDAIVTPLNM AANNLEHIAR GEIPAKITAS FNGDFNNIKH NLNTCITSIN
ALVSDVNILS NAANEGRVSV RVDASTHLGD FRKIVEGVNE TLEMIVGPIA TVKASVETIN
TAAAEITSGN NDLSARTEKQ VSSLEQTAAS MEELASTVKR NADNAKRANQ LALNASDVAV
KGGEVVSDAV VTMNAINDSA HKIEDIIAVI DSIAFQTNIL ALNAAVEAAR AGEQGRGFAV
VAGEVRSLAQ RSASAAKEIK ALINDSVSKT FEGTKQVENA GKTMEEVVAS VKQVADIISE
IATASVEQST GIDQVNNAMN SMDEATQQNA ALVEEATAAA ESLLEQASAL ADAVSVFKLD
DTNITLADNV IEMHPALRPH AIVRPNVIRP NTVARQNTPV KPQFADMQTQ AKRVITAEYV
NAHWEHV
//
