ID C6X168_FLAB3 Unreviewed; 600 AA.
AC C6X168;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Beta-xylosidase {ECO:0000313|EMBL:ACU08181.1};
DE EC=3.2.1.37 {ECO:0000313|EMBL:ACU08181.1};
GN OrderedLocusNames=FIC_01738 {ECO:0000313|EMBL:ACU08181.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU08181.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU08181.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU08181.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR EMBL; CP001673; ACU08181.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X168; -.
DR STRING; 531844.FIC_01738; -.
DR CAZy; GH43; Glycoside Hydrolase Family 43.
DR KEGG; fba:FIC_01738; -.
DR eggNOG; COG3507; Bacteria.
DR HOGENOM; CLU_016508_2_0_10; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0009044; F:xylan 1,4-beta-xylosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd18617; GH43_XynB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF12; BETA-XYLOSIDASE-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000001512}.
FT DOMAIN 423..593
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT ACT_SITE 96
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 272
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 205
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 600 AA; 67065 MW; E13FCFFDFB8CEA46 CRC64;
MVRLLIKIFR RLKYHYPDYI IPLLKSRSNK KIFENMASFH KNRTALVAAI ALLSANSISA
QIFSNFEYRG NDKIYTQNPL KDNEFYSPIL QGCYPDPSIT RKGDDYYLVN SSFSMFPGVP
IFHSKDLVNW KQLGHVLDRP SQLKVEKAGF SEGIYAPAIK YNKYNDTFYM ITTQIASDIG
NMVVKTKDPA NGWGEVQKLN FDGIDPSLFF DEDGKAYVVH NDAPPAGTER YSGHRVIKVW
DYDLEKDQVI AGTDKIIVNG GVDLSQNPIW IEAPHIYKKD GKYFLICAEG GTGGNHSEVV
FISDSPRGPY LPAPSNPILT QRYFPKERKE KVDWAGHADL VEGPDGKYYG VFLGIRPNDK
HRVNTGRETF ILPVDWSGTF PVFENGLVPM KPKMAMPTGI KNQTGTNGFL PNGNFTFKDP
LTAKNLDFKW IAMRGPRENF ISSAKNGVKI IPFPVNIKAK SPVSALFHRQ QHAAFEAEVS
VDFKPKSENE LSGITCYQSE NFNYVFGITK KDKDFYIVLE RTEKGASTIL ASEKITLSKP
VKLQVTADGD DYRFSYATDG KNFVNLGGTV SGDILSTDVA GGFTGALIGL YSTVANDIKL
//
