ID C6X525_FLAB3 Unreviewed; 590 AA.
AC C6X525;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:ACU07513.1};
DE EC=3.4.11.9 {ECO:0000313|EMBL:ACU07513.1};
GN OrderedLocusNames=FIC_01063 {ECO:0000313|EMBL:ACU07513.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU07513.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU07513.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU07513.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; CP001673; ACU07513.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X525; -.
DR STRING; 531844.FIC_01063; -.
DR KEGG; fba:FIC_01063; -.
DR eggNOG; COG0006; Bacteria.
DR HOGENOM; CLU_011781_2_4_10; -.
DR OrthoDB; 9806388at2; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ACU07513.1};
KW Hydrolase {ECO:0000313|EMBL:ACU07513.1};
KW Protease {ECO:0000313|EMBL:ACU07513.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001512}.
FT DOMAIN 7..138
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 308..522
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 530..590
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 590 AA; 66593 MW; DFE0260F2897F783 CRC64;
MTSSEKISAL RQKMQQNNID AFIVYSADPH MSEYLPEEWQ ERAWLSGFTG SAGFVVVTKD
KAGLWTDGRY FVQAPKELQG SGIDLMKEGD EATPNYIDWI ISEISQDGKV AVNALATSNT
NWETLEQKLA VKNIEVVDMP LLKEVWLERT LDKKKNPVFV HPLERAGKSV SDKLGDIRSK
MKELNASLHI ISSLDDVAWT LNLRGSDVQS NPVFLGYIIL TNEEAVLFVD QEKLDDDAKN
QMQKSSVSVR DYEDFFAYLK NIKDQKILIS ANSNQSIIEA LKENNTFIKA PVPGNLMKAV
KNDTELEGFR TVMQRDGVAM VKFLYWLTHQ AGKETMNEFS IGEKLRGFRA EGDNFVGESF
GSIVGFKENG AIMHYSAPKE GSKEVTSEDT ILVDSGGQYL EGTTDITRTF ALGNASEEFK
RNSTLALKGL IQLSMVKFPK GTRGVQLDAF ARLALWKEGK DYNHGTGHGV GSFMNVHEGP
QNIRKDMNPQ ELIPGMVLSN EPGFYLENHY GIRHENLIAV KEAEKTDFGT FYEFETLTIC
PFDRNVIEVD LLTQPEKEWL NSYHEWCREK LENSLEGEVK AWFLEQVQPL
//
