ID C6X597_FLAB3 Unreviewed; 652 AA.
AC C6X597;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Two-component system sensor histidine kinase {ECO:0000313|EMBL:ACU07585.1};
DE EC=2.7.3.- {ECO:0000313|EMBL:ACU07585.1};
GN OrderedLocusNames=FIC_01135 {ECO:0000313|EMBL:ACU07585.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU07585.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU07585.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU07585.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
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DR EMBL; CP001673; ACU07585.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X597; -.
DR STRING; 531844.FIC_01135; -.
DR KEGG; fba:FIC_01135; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG4585; Bacteria.
DR HOGENOM; CLU_000445_106_2_10; -.
DR OrthoDB; 9778366at2; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13424; TPR_12; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACU07585.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001512};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACU07585.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 86..119
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 166..199
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 455..651
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 652 AA; 73576 MW; F56A84F583BCF45B CRC64;
MKRFTTYTAD NFLGLDPVWR LLMLLLISAT LSCNSPDKTA DAQQSELESQ LEEIHKLVYA
EPSLARDRSL KILQSISPGT DIKAEIISLK YIGSSYAVET RYAEAIKYYK RALELAEKIN
LYSETANLNN NLGTIYNEFG NYGAAYIYFI KALENYELAE NKEKRSGTLN NIGLTYLSLG
NREKALGYFS GALKASQSGK DTILTATILN NIALCNFAEK KIALGLENLK RSISLSEKTR
NVYGLCVSYQ ILGNMYLDEQ KTQKAFEAYS TSIGIAERAH LNHLLAVSKI GLARVLLSQN
KTGEALRYAE EVMAVSNEKN SQSLKADAHQ LLSGIYEKNG NLELSLKEFR DYVKIKEELN
NTTVVNQIYD VEVDYLNQLN KMQQLELEKK ELAISNKNIW LFFLSLIFLM IFGGAYLIYR
NYRGKQKVKL QQTILELTKK KSNAALEAEI EERKRIGREL HDSLGYLLSL AGLNASVLQK
RKELPEEKKS ELLNSLMESI NDAFDEVRTI SHNLAPSLLS EQGLKGALKN ISDKVNQSNR
LKMSFDTFGL HHQLDELVEN VLYRTLQEIV NNTIKHADAT ELFVQIAQDR HQITLMAEDN
GKGFDTDSLK TKASFGLSHI KSWIENLNGS IHVDSKIKRG TIISILIPVE NE
//
