ID C6X8X3_METGS Unreviewed; 904 AA.
AC C6X8X3;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Molybdopterin oxidoreductase {ECO:0000313|EMBL:ACT49593.1};
GN OrderedLocusNames=Msip34_0344 {ECO:0000313|EMBL:ACT49593.1};
OS Methylovorus glucosotrophus (strain SIP3-4).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylovorus.
OX NCBI_TaxID=582744 {ECO:0000313|EMBL:ACT49593.1, ECO:0000313|Proteomes:UP000002743};
RN [1] {ECO:0000313|Proteomes:UP000002743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SIP3-4 {ECO:0000313|Proteomes:UP000002743};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.;
RT "Complete sequence of chromosome of Methylovorus sp. SIP3-4.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACT49593.1, ECO:0000313|Proteomes:UP000002743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SIP3-4 {ECO:0000313|EMBL:ACT49593.1,
RC ECO:0000313|Proteomes:UP000002743};
RX PubMed=21622745; DOI=10.1128/JB.00404-11;
RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT "Genomes of three methylotrophs from a single niche uncover genetic and
RT metabolic divergence of Methylophilaceae.";
RL J. Bacteriol. 193:3757-3764(2011).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
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DR EMBL; CP001674; ACT49593.1; -; Genomic_DNA.
DR RefSeq; WP_015829277.1; NC_012969.1.
DR AlphaFoldDB; C6X8X3; -.
DR STRING; 582744.Msip34_0344; -.
DR KEGG; mei:Msip34_0344; -.
DR eggNOG; COG0243; Bacteria.
DR eggNOG; COG1251; Bacteria.
DR HOGENOM; CLU_000422_13_4_4; -.
DR OrthoDB; 7376058at2; -.
DR Proteomes; UP000002743; Chromosome.
DR GO; GO:1990204; C:oxidoreductase complex; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0045333; P:cellular respiration; IEA:UniProt.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04324; Fer2_BFD; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002743}.
FT DOMAIN 2..58
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 904 AA; 99371 MW; 30C366739051C478 CRC64;
MLKETRSTCC YCGVGCGVII TSEDDRITGV RGDPDHPANF GRLCTKGSTL HLTAKLDTRV
LQPEMRTSRH SPRQPTDWDT ALDHVADRFA ETIREHGPNS VAFYISGQLL TEDYYVFNKL
AKGLIGTNNV DTNSRLCMSS AVSGYKLTLG ADAPPACYED IDHTACLFIA GSNTAYAHPI
IFRRIEDAKA RNPDMKIVVV DPRRTDTATF ADLHLAIQPG TDVALFNGML HIMLWEGMLD
QAFIREHTNG FDALKETVRE YTPKMVADIC GIREADLVTA AKWFGSGPSL SMYCMGLNQS
IHGSDKNAAL INLHLATGQI GKPGAGPFSL TGQPNAMGGR EVGGMANLLS GHRDLDNPEH
RAEVAALWGV EDVPATPGKT AVEMFDALKS GEIKAIWIAC TNPAHSMPDL NQVRAALENA
ELVVLQDAYG NTDTNIYADV VLPATSWGEK EGTVTNSERR ITHITPAVAK PGAARHDWEI
VVDFAQRLEQ RLGKANTLFN YLVPETIFNE HRESTRGRDL DITGLSYQIL DTQGPQQWPL
NEKVSTGLQR LYSDGIFPKP DGRAQFHIAH YKPTADKTDA RQPLHLLTGR LRDQWHGMSR
TGTVAQLFNH VDEPVISLNQ QDMERRQIKP GDLVKVSNKR GSLTLRAQPS DEIQPAQSFI
PMHWGSQFMS GLGCNALMPS AFDKISRQPE LKHTAVKLEK VELAWQMTVM RNSNDMHLLE
AIRRLLPGFD YASCGLYGRG NGMVVLQAAH HAAPDAAVID ALDALLGMTE GAPMLNYQDA
RRGISKRILV EPDVATGRQQ VTGVRLIGET LAAEWLREVM TEGQFSDELR RWALAPLSAP
PTGQRSRGKI VCNCLNVAEN EIIDTIQMGA DFITLQNKLK CGTQCGSCVP ELKKLVQLHG
RTAA
//
