ID C6XDC9_METGS Unreviewed; 309 AA.
AC C6XDC9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Transcriptional regulator, MerR family {ECO:0000313|EMBL:ACT50554.1};
GN OrderedLocusNames=Msip34_1308 {ECO:0000313|EMBL:ACT50554.1};
OS Methylovorus glucosotrophus (strain SIP3-4).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylovorus.
OX NCBI_TaxID=582744 {ECO:0000313|EMBL:ACT50554.1, ECO:0000313|Proteomes:UP000002743};
RN [1] {ECO:0000313|Proteomes:UP000002743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SIP3-4 {ECO:0000313|Proteomes:UP000002743};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.;
RT "Complete sequence of chromosome of Methylovorus sp. SIP3-4.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACT50554.1, ECO:0000313|Proteomes:UP000002743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SIP3-4 {ECO:0000313|EMBL:ACT50554.1,
RC ECO:0000313|Proteomes:UP000002743};
RX PubMed=21622745; DOI=10.1128/JB.00404-11;
RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT "Genomes of three methylotrophs from a single niche uncover genetic and
RT metabolic divergence of Methylophilaceae.";
RL J. Bacteriol. 193:3757-3764(2011).
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DR EMBL; CP001674; ACT50554.1; -; Genomic_DNA.
DR RefSeq; WP_015830031.1; NC_012969.1.
DR AlphaFoldDB; C6XDC9; -.
DR STRING; 582744.Msip34_1308; -.
DR KEGG; mei:Msip34_1308; -.
DR eggNOG; COG0789; Bacteria.
DR eggNOG; COG5012; Bacteria.
DR HOGENOM; CLU_045945_3_1_4; -.
DR OrthoDB; 9800334at2; -.
DR Proteomes; UP000002743; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd02065; B12-binding_like; 1.
DR CDD; cd01104; HTH_MlrA-CarA; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR30204:SF67; HTH-TYPE TRANSCRIPTIONAL REGULATOR MLRA-RELATED; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR Pfam; PF13411; MerR_1; 1.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002743}.
FT DOMAIN 8..77
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
FT DOMAIN 176..303
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 309 AA; 34683 MW; 9CB6EE77C64FDDFD CRC64;
MPNPDVDAYP IRTVSALTGI NPVTLRTWER RYRLIEPVRT PKGHRLYTKD QIAILHRVVD
LLDKGIPISR INFSLISGEA NTYSNQEEEF WNRLITRMTA AVANFDEVVL ESTYNEALSL
YSIEIVTDML LMPMLIRLGE RWERGDGTVA EEHFFGVYLR NKLGARFHHR KRRDYGPALL
TACMPGERHE AGILLFALSA YDHGYRCILL GTDMPLEELP AAVVQSKSRG IVLSASFISD
ASLIKRQLTH LVNATNVPVF VGGQSSVTLH DAIKEAGAVP LGMEIEQSFK RIAESFKNKF
AQSLNVASV
//
