ID C6XKH2_HIRBI Unreviewed; 405 AA.
AC C6XKH2;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Threonine dehydratase {ECO:0000313|EMBL:ACT57770.1};
GN OrderedLocusNames=Hbal_0068 {ECO:0000313|EMBL:ACT57770.1};
OS Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC Hyphomonadaceae; Hirschia.
OX NCBI_TaxID=582402 {ECO:0000313|EMBL:ACT57770.1, ECO:0000313|Proteomes:UP000002745};
RN [1] {ECO:0000313|Proteomes:UP000002745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49814 / DSM 5838 / IFAM 1418
RC {ECO:0000313|Proteomes:UP000002745};
RX PubMed=21705585; DOI=10.1128/JB.05453-11;
RG US DOE Joint Genome Institute;
RA Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL J. Bacteriol. 193:4567-4568(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; CP001678; ACT57770.1; -; Genomic_DNA.
DR AlphaFoldDB; C6XKH2; -.
DR STRING; 582402.Hbal_0068; -.
DR KEGG; hba:Hbal_0068; -.
DR eggNOG; COG1171; Bacteria.
DR HOGENOM; CLU_021152_4_1_5; -.
DR Proteomes; UP000002745; Chromosome.
DR GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0004794; F:L-threonine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006567; P:threonine catabolic process; IEA:InterPro.
DR CDD; cd04886; ACT_ThrD-II-like; 1.
DR CDD; cd01562; Thr-dehyd; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR044561; ACT_ThrD-II-like.
DR InterPro; IPR005789; Thr_deHydtase_catblc.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01127; ilvA_1Cterm; 1.
DR PANTHER; PTHR48078:SF6; ACT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48078; THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51671; ACT; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Isoleucine biosynthesis {ECO:0000256|ARBA:ARBA00022624};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002745}.
FT DOMAIN 330..405
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 405 AA; 43318 MW; 6B7D754AB42589D7 CRC64;
MTDAKTISYE DILAAAKELE GELERTPMRK SRTLSEITGA EIWIKFENLQ FTAAFKERGA
LNKLKSLTEA EKKAGVVAMS AGNHAQGVAY HAARLGIPAT IVMPKSTPFV KVEHTRNYGA
RVILHGEMLT ESDAYARELE AKEGLTFIHP YDDAKVVAGQ GTIALEMLED QPDLEYLVVP
VGGGGLIGGM TVAAKHINPD IHIVGVEPSM YPSLTAEMRN EEAQVGGATI AEGIAVKKVG
EIGAAICREM MDEVLLVEEE HLERAITLLA TVEKTVAEGA GAAGLAALLA YPQKFSGRRV
GLVVCGGNID TRLLASVLTR SLVREKRLAS IRMVGGDNPG LLADVSRIIG EGGANIIEVA
HNRIALDVPA KGAEFDILIE TRDAQHTQDI VDALSRAGFP PRSQD
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