ID   C6XN50_HIRBI            Unreviewed;       581 AA.
AC   C6XN50;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   OrderedLocusNames=Hbal_0518 {ECO:0000313|EMBL:ACT58220.1};
OS   Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC   Hyphomonadaceae; Hirschia.
OX   NCBI_TaxID=582402 {ECO:0000313|EMBL:ACT58220.1, ECO:0000313|Proteomes:UP000002745};
RN   [1] {ECO:0000313|Proteomes:UP000002745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49814 / DSM 5838 / IFAM 1418
RC   {ECO:0000313|Proteomes:UP000002745};
RX   PubMed=21705585; DOI=10.1128/JB.05453-11;
RG   US DOE Joint Genome Institute;
RA   Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT   "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL   J. Bacteriol. 193:4567-4568(2011).
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DR   EMBL; CP001678; ACT58220.1; -; Genomic_DNA.
DR   RefSeq; WP_015826370.1; NC_012982.1.
DR   AlphaFoldDB; C6XN50; -.
DR   STRING; 582402.Hbal_0518; -.
DR   KEGG; hba:Hbal_0518; -.
DR   eggNOG; COG2319; Bacteria.
DR   HOGENOM; CLU_469116_0_0_5; -.
DR   OrthoDB; 8256315at2; -.
DR   Proteomes; UP000002745; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002745};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        213..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..130
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
SQ   SEQUENCE   581 AA;  63332 MW;  7491EF9E611E228A CRC64;
     MIDTPSNALR VYICCAQADL SFANELLTGL TTCGFEVITS FNPASLPAPP KLEIEDRIAT
     SDTVLFILTP DALNDSKATS ELEDAYNMGK RLYLIPIKPI SSGDAPEAML QLPYVSFQGD
     TSFAQNLATL VAKLKTNHSW VQEHTRLSKS AIKWLNHGKA HSLLLFGREL DRAMSWRANK
     PQTSSHITKL QDAFINASLA AYKNKSEKKQ RAGFGKFGLT LIAAGICACA YFGVSWQETK
     KLNFELSEKL SSTTQLNNQL EAVQTRLYAD MRLAPSSNTD GVLTHISGWY PRASSHAGSV
     ARIQFPTEQS SIPHDTQYTG LIIAGELLGE AYRDKNYILT PTFNLADSPL NDGLLASNSP
     QAPTVNDNAN FHFVANRTSE RVLLAVVQPS SNESYDIQLP ALHGSKQIQA MGTAWQSQLK
     NGDRPAFSLH QIPDTLPTGA RAISISDIDC QKFTRIKSLG RAQAEDLNTQ FEPIGIFSLA
     PTIQQNQDFS IPSNLGYATI EISNLQSETG RSHVIYKRGT ITPETGAPVF NLTTGKIIAL
     HIGESSSAEN FEGVSLESLL NEVRADLSSP TSNINSICAA F
//