ID C6XS60_PEDHD Unreviewed; 1058 AA.
AC C6XS60;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family {ECO:0000313|EMBL:ACU03405.1};
GN OrderedLocusNames=Phep_1187 {ECO:0000313|EMBL:ACU03405.1};
OS Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457
OS / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=485917 {ECO:0000313|EMBL:ACU03405.1, ECO:0000313|Proteomes:UP000000852};
RN [1] {ECO:0000313|EMBL:ACU03405.1, ECO:0000313|Proteomes:UP000000852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 /
RC NCIMB 9290 / NRRL B-14731 / HIM 762-3
RC {ECO:0000313|Proteomes:UP000000852};
RX PubMed=21304637; DOI=10.4056/sigs.22138;
RA Han C., Spring S., Lapidus A., Del Rio T.G., Tice H., Copeland A.,
RA Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.C., Saunders E., Chertkov O.,
RA Brettin T., Goker M., Rohde M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT "Complete genome sequence of Pedobacter heparinus type strain (HIM 762-
RT 3).";
RL Stand. Genomic Sci. 1:54-62(2009).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP001681; ACU03405.1; -; Genomic_DNA.
DR RefSeq; WP_012781349.1; NZ_AQGK01000001.1.
DR AlphaFoldDB; C6XS60; -.
DR STRING; 485917.Phep_1187; -.
DR KEGG; phe:Phep_1187; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_1_10; -.
DR OrthoDB; 9758234at2; -.
DR Proteomes; UP000000852; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1058 AA; 114695 MW; F54D30EDCACE33F8 CRC64;
MFKKFIERPV LSTVISIIIV ILGILGLITL PVSQYPEIAP PTVQVSASYQ GANADVVMSS
VVVPLEEQIN GVEDMTYMTS SAGNDGTATI TVNFKLGTNP DLAAVNVQNR VARATSLLPA
EVTRAGVITA KKQASNVLIF AIYSDSASYD QKFLQNYANI NLIPQIKRIN GVGDATAFGL
MDYSMRIWLK PEVMATYGLV PNDISVVLAE QNIEAAPGQF GEQGDQSFQY TLKYSGRLKN
ETEFSNIIVR TAQNGQVLRL KDIARIELGA QSYSSSVKFN GKPALGIAIN QTAGSNAKEV
IEGAIKVLDE SSVNFPKGVH YTALINVNDF LDASIEKVIH TLIEAFILVF LVVFIFLQDF
RSTLIPAISV PVAIIGTFFF LSLFGFTINL LTLFALVLAI GIVVDDAIVV VEAVHAKLDH
GYTSAKKATI DAMEDITGAI ISITLVMAAV FIPVSFIQGS SGVFYKQFGL TLAIAIILSA
INALTLSPAL CALFLKPHAE DHNKPKNFMQ RFYTAFNASF DAMTNRYKRS VSFLARRKWI
AGLGIVLFTI VLIWTMSTTP KGFVPNEDLG TVMSDISLPP ATSQEQTALV IKKIDSIAHT
IPEIKFSLTV VGRSMISGTG SSYGMVIGKL KPWDERQRDV KAIIAELFAK TASIKGARII
FFAPPTIQGF GTGGGFEFQL QDKTGGDINK FSNIANGFLA ALAKRPEIQY ASTSFNPNFP
QYQIDVNVAT VKQAGLSVSD VLAVLQGYYG GVYASNFNKF GKQYRVMYQA DAQYRANEQT
LNNIYVRNSG GQMAPISNFI TLKKVYGPQA ISRFNLFTSI AVTGNPNAGY SSGDALKAVQ
EEAAIHLPTG YGYEFSGLSR EEMSSGSQTI FIFLLCVIFV YFLLCAQYES YILPLAVLIS
LPIGLAGVFI FDKIFKVDNN IYTQITLIML VGLLAKNAIL IVEFAVDRRR KGMSIVGAAI
SGATARLRPI LMTSFAFILG LLPLMLSTGV GAAGNKSIGT GAVGGMLIGT LFGVFVIPAL
FIVFQSIQEK VSSKSPFDEG YGPRQEVIEF PEVDTREH
//
