ID C6XSG4_PEDHD Unreviewed; 979 AA.
AC C6XSG4;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN OrderedLocusNames=Phep_1294 {ECO:0000313|EMBL:ACU03509.1};
OS Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457
OS / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=485917 {ECO:0000313|EMBL:ACU03509.1, ECO:0000313|Proteomes:UP000000852};
RN [1] {ECO:0000313|EMBL:ACU03509.1, ECO:0000313|Proteomes:UP000000852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 /
RC NCIMB 9290 / NRRL B-14731 / HIM 762-3
RC {ECO:0000313|Proteomes:UP000000852};
RX PubMed=21304637; DOI=10.4056/sigs.22138;
RA Han C., Spring S., Lapidus A., Del Rio T.G., Tice H., Copeland A.,
RA Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.C., Saunders E., Chertkov O.,
RA Brettin T., Goker M., Rohde M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT "Complete genome sequence of Pedobacter heparinus type strain (HIM 762-
RT 3).";
RL Stand. Genomic Sci. 1:54-62(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; CP001681; ACU03509.1; -; Genomic_DNA.
DR AlphaFoldDB; C6XSG4; -.
DR STRING; 485917.Phep_1294; -.
DR CAZy; GH2; Glycoside Hydrolase Family 2.
DR KEGG; phe:Phep_1294; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_308751_0_0_10; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000000852; Chromosome.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACU03509.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000852};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..979
FT /note="beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002974196"
FT DOMAIN 61..126
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 131..325
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 979 AA; 108973 MW; 6F858070F4B1C644 CRC64;
MMKRALLLSF LFLIQISFST AQSAYQLTPF TGVDYVRVVV SSAFKTAPDN TFKLLISSPK
DGKVLWQGPV KATTAVNEGN NHLAFTVSNL KPVLWTPHNP FLYNVTLQQY SGKTLKAELK
ERAGFRSFER RKGNLYLNGK PIFLRGIAIN PPGRGIPDEL ETSRAFALDY VKYMKSINVN
IIRIPDEEAW FDVCDELGMM VFGGNYSGKV AAGEKVKDQE KVGDETDGGF PKDHDKGVAW
YENEKLGAIA HHPSLMVYAM TNETPFKGSR ADAWEKFLDY AFGKLKKWDE TRVYIANAGY
GYGKTGDILD IHRYWGWYYS SPFTFLHIRD HAKIVPYPKK EDMPITFTEC VGNYTGPDGR
YNLTPQHKNP SSQLAWTGHE RQDLQAQLAD EHQSFTLRQA TESFRQLRSV NPDLSGVFPF
TILFYNWNTI EKFADMKPKP VTDQVKISYQ PVLLSWECWT PNVYAGAEIN PVAHISNDDN
DFKDLKNAKL VYQIRDKAYS IVFSDSVNIG DIPYYSTAKK KLSIRLPKDL NSGKYELTGK
IISAGKQVSY NYYKLFIADD NFTKAVVPIE SVESSVLLYD KEGKTRKSLA ALGLKFNSIG
SFGKLPEKGV LIIGENAADQ ELAGNATAIR NFINGGGRVV ALRQDSLRMI NLNQLAIHKL
VNRNVDIDDP VYPVSSKSPR NGYYVNAERP NHPLFAGITR ENMRIWSDYT NWDETKAGLP
AIKPVTDGFV LENKEDVANT AILANYSSGL QGIAIAEQFM GNGSLLLCGL DISNRTSVDP
VAARIMLNMV SYAASATGHE QHQLISSPIV WGEYETEKGI VVDAYSGFLV NATPRVPPNY
LGKGIVVTKE GYQLAGGNRS GFNTRPGIQY VANGRRPFGP YVQSFGGQPL PDKDSTEGVG
SFWCRIPQGQ NLATSVAWNP AKEPVQLKIK VNDLAEVNKT IPAGAKIAIE TPVNAEVVKM
TYSGDRRVVI LETAFSKKN
//
