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Database: UniProt
Entry: C6XW01_PEDHD
LinkDB: C6XW01_PEDHD
Original site: C6XW01_PEDHD 
ID   C6XW01_PEDHD            Unreviewed;       440 AA.
AC   C6XW01;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=Phep_1872 {ECO:0000313|EMBL:ACU04080.1};
OS   Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM
OS   7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3).
OC   Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=485917 {ECO:0000313|EMBL:ACU04080.1, ECO:0000313|Proteomes:UP000000852};
RN   [1] {ECO:0000313|EMBL:ACU04080.1, ECO:0000313|Proteomes:UP000000852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 /
RC   NCIMB 9290 / NRRL B-14731 / HIM 762-3
RC   {ECO:0000313|Proteomes:UP000000852};
RX   PubMed=21304637; DOI=10.4056/sigs.22138;
RA   Han C., Spring S., Lapidus A., Del Rio T.G., Tice H., Copeland A.,
RA   Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L.,
RA   Pitluck S., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA   Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Saunders E., Chertkov O., Brettin T., Goker M.,
RA   Rohde M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of Pedobacter heparinus type strain (HIM
RT   762-3).";
RL   Stand. Genomic Sci. 1:54-62(2009).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP001681; ACU04080.1; -; Genomic_DNA.
DR   RefSeq; WP_015807694.1; NZ_AQGK01000001.1.
DR   STRING; 485917.Phep_1872; -.
DR   EnsemblBacteria; ACU04080; ACU04080; Phep_1872.
DR   KEGG; phe:Phep_1872; -.
DR   eggNOG; ENOG4105C7S; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   HOGENOM; HOG000281564; -.
DR   KO; K00658; -.
DR   OMA; FTPIFME; -.
DR   OrthoDB; 1626282at2; -.
DR   BioCyc; PHEP485917:G1GFH-1878-MONOMER; -.
DR   Proteomes; UP000000852; Chromosome.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000852};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000852};
KW   Transferase {ECO:0000256|RuleBase:RU003423}.
FT   DOMAIN        3     78       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      124    164       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
SQ   SEQUENCE   440 AA;  47900 MW;  96387F20188E5F24 CRC64;
     MAQYELLLPK MGESVAEATI IKWVKQPGEL IEMDDTVLEI ATDKVDSEVP SPIAGRLVKQ
     LFKEDDIVQV GAVIAIIETD ADAPVVAEQA VETPAAVSVP EAEPVTANIP GMEQLPADFV
     SDRFYSPLVK NIALQEGITV EELDTISGTG AEGRLTKDDL LNYIQNGKKT GDVSREEEVK
     PVAQQSAVAQ PLKVQPTQAA ASISGGDEII EMDRMRKLIA EHMVMSKQTS PHVTSFVEAD
     VTNMVLWREK VKRDFEKREN EKITFTPIFV EAVSRAIKDF PMINVSVNGN QIIKKKDINI
     GMAAALPSGN LIVPVIKNAD ELNLLGLTKA VNDLASRARA SKLKPDETQN GTFTLTNVGS
     FGNVMGTPII NQPQVAILAV GAIKKKPAVL ETEAGDVIAI RHIMFLSLSY DHRVVDGALG
     GSFVRRVADY LEKWDLNREI
//
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