ID C7BKK1_PHOAA Unreviewed; 415 AA.
AC C7BKK1;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=N-acetylmuramoyl-L-alanine amidase {ECO:0000256|ARBA:ARBA00011901};
DE EC=3.5.1.28 {ECO:0000256|ARBA:ARBA00011901};
GN Name=amiC {ECO:0000313|EMBL:CAQ82687.1};
GN OrderedLocusNames=PAU_00595 {ECO:0000313|EMBL:CAQ82687.1};
OS Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
OS (Xenorhabdus luminescens (strain 2)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=553480 {ECO:0000313|EMBL:CAQ82687.1, ECO:0000313|Proteomes:UP000002747};
RN [1] {ECO:0000313|EMBL:CAQ82687.1, ECO:0000313|Proteomes:UP000002747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43949 / 3105-77 {ECO:0000313|Proteomes:UP000002747};
RX PubMed=19583835; DOI=10.1186/1471-2164-10-302;
RA Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
RA Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
RA Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C.,
RA Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.;
RT "Comparative genomics of the emerging human pathogen Photorhabdus
RT asymbiotica with the insect pathogen Photorhabdus luminescens.";
RL BMC Genomics 10:302-302(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes the link between N-acetylmuramoyl residues and L-
CC amino acid residues in certain cell-wall glycopeptides.; EC=3.5.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001561};
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DR EMBL; FM162591; CAQ82687.1; -; Genomic_DNA.
DR AlphaFoldDB; C7BKK1; -.
DR STRING; 291112.PAU_00595; -.
DR KEGG; pay:PAU_00595; -.
DR eggNOG; COG0860; Bacteria.
DR Proteomes; UP000002747; Chromosome.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd02696; MurNAc-LAA; 1.
DR Gene3D; 2.60.40.3500; -; 1.
DR Gene3D; 3.40.630.40; Zn-dependent exopeptidases; 1.
DR InterPro; IPR021731; AMIN_dom.
DR InterPro; IPR002508; MurNAc-LAA_cat.
DR NCBIfam; NF038267; amidase_AmiC; 1.
DR PANTHER; PTHR30404; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR PANTHER; PTHR30404:SF0; N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC; 1.
DR Pfam; PF01520; Amidase_3; 1.
DR Pfam; PF11741; AMIN; 1.
DR SMART; SM00646; Ami_3; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAQ82687.1}.
FT DOMAIN 249..403
FT /note="MurNAc-LAA"
FT /evidence="ECO:0000259|SMART:SM00646"
SQ SEQUENCE 415 AA; 46376 MW; 66B2FDFB03B31B94 CRC64;
MSHSDHNLSR RRLLQGAAAM WLLSVSHVGY ASSSKIIAVR IWPASSYTRV TLESNIPLKY
RQFMLTNPNR IVVDLEGVQL NHTLKGMGEQ IQSRDPYLKL VRAGQFDPKT VRLVFEVKQP
VSPHMFTLKP VAEFKHRLVL DLYPAAGTNT DDDPLLALLE EYNKGNLAED LPAKTPKPGK
AGKDRPIVIM LDPGHGGEDP GAIGKYKTRE KDVVLQIARR LKSIIQREPD MKVYMTRNED
VFIPLKVRVA KARKMRADLF VSIHADAFTN RAARGSSVFA LSTKGATSNT ARFLAQTQNE
ADQIGGVSKS GDKYLDHTMF DLLQTATIND SLKFGSEVLR RMGKVNKLHK NRVDQAGFAV
LKAPDIPSIL VETAFISNLE EERKLKTARF QQQVAESIFA GIKAYFRNGG DLVRR
//
