ID C7FZZ0_DICDI Unreviewed; 357 AA.
AC C7FZZ0;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=SH3 domain-containing protein {ECO:0000313|EMBL:EEU04127.1};
GN ORFNames=DDB_G0274805 {ECO:0000313|EMBL:EEU04127.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EEU04127.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EEU04127.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EEU04127.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EEU04127.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EEU04127.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3] {ECO:0007829|PDB:4NQI}
RP X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 2-259.
RX PubMed=24463811; DOI=10.1242/jcs.140756;
RA Linkner J., Witte G., Zhao H., Junemann A., Nordholz B., Runge-Wollmann P.,
RA Lappalainen P., Faix J.;
RT "The inverse BAR domain protein IBARa drives membrane remodeling to control
RT osmoregulation, phagocytosis and cytokinesis.";
RL J. Cell Sci. 127:1279-1292(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEU04127.1}.
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DR EMBL; AAFI02000012; EEU04127.1; -; Genomic_DNA.
DR RefSeq; XP_002649179.1; XM_002649133.1.
DR PDB; 4NQI; X-ray; 2.21 A; A/B/C/D=2-259.
DR PDBsum; 4NQI; -.
DR AlphaFoldDB; C7FZZ0; -.
DR SMR; C7FZZ0; -.
DR PaxDb; 44689-DDB0266618; -.
DR EnsemblProtists; EEU04127; EEU04127; DDB_G0274805.
DR GeneID; 8619366; -.
DR KEGG; ddi:DDB_G0274805; -.
DR dictyBase; DDB_G0274805; ibrA.
DR eggNOG; KOG2856; Eukaryota.
DR HOGENOM; CLU_777125_0_0_1; -.
DR InParanoid; C7FZZ0; -.
DR OMA; FITPCKQ; -.
DR PhylomeDB; C7FZZ0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0031164; C:contractile vacuolar membrane; IDA:dictyBase.
DR GO; GO:0032433; C:filopodium tip; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:dictyBase.
DR GO; GO:0022607; P:cellular component assembly; IEA:UniProt.
DR GO; GO:0071476; P:cellular hypotonic response; IMP:dictyBase.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEP:dictyBase.
DR GO; GO:0009992; P:intracellular water homeostasis; IMP:dictyBase.
DR GO; GO:0010324; P:membrane invagination; IDA:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IEP:dictyBase.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR GO; GO:0140028; P:pore formation during contractile vacuole discharge; IMP:dictyBase.
DR GO; GO:0031150; P:sorocarp stalk development; IMP:dictyBase.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF20; PROTEIN NERVOUS WRECK; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4NQI}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..239
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 298..357
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 117..174
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 357 AA; 40170 MW; 2B49B059BA1DB737 CRC64;
MSNAKKQQNP GIEITLKTIN NLKVNSPPLF TEVIKAANKY QQQAQALSQA GLVLADTLTR
LTIHNGGDFG EGFKKLADAI KDLENRRDDV AKVLLNEFIT PNKQAIEDDQ KAIATFEKNY
KKDRDQMRQD ILKLEAKTRK AGKKTTPEVL KQQITELNDK IKESEQLNAN KLRDVVLMER
RKHATFLSQF NQFLEKEIEL SADTMSKFST NLNTHRDLIN SQSQLPLEME SMISKQERTL
VQIQPQGDTG SDAYRISYAP GTIQTTGGGD QYYESYESYD NYDNYDNYDD GGSGGLGGSE
LQARALYDYE SAEPSDLNLK AGDIISVIQQ DDGSGWTKGR NYEGNEGIFP STYIEYV
//
