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Database: UniProt
Entry: C7H6X2_9FIRM
LinkDB: C7H6X2_9FIRM
Original site: C7H6X2_9FIRM 
ID   C7H6X2_9FIRM            Unreviewed;       407 AA.
AC   C7H6X2;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   28-MAR-2018, entry version 51.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:EEU96347.1};
GN   ORFNames=FAEPRAA2165_02055 {ECO:0000313|EMBL:EEU96347.1};
OS   Faecalibacterium prausnitzii A2-165.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Faecalibacterium.
OX   NCBI_TaxID=411483 {ECO:0000313|EMBL:EEU96347.1, ECO:0000313|Proteomes:UP000004619};
RN   [1] {ECO:0000313|EMBL:EEU96347.1, ECO:0000313|Proteomes:UP000004619}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A2-165 {ECO:0000313|EMBL:EEU96347.1,
RC   ECO:0000313|Proteomes:UP000004619};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA   Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA   Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA   Mitreva M., Nelson J., Hou S., Wollam A., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Warren W., Chinwalla A., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEU96347.1}.
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DR   EMBL; ACOP02000051; EEU96347.1; -; Genomic_DNA.
DR   RefSeq; WP_005933704.1; NZ_GG697152.2.
DR   STRING; 411483.FAEPRAA2165_02055; -.
DR   EnsemblBacteria; EEU96347; EEU96347; FAEPRAA2165_02055.
DR   GeneID; 34752532; -.
DR   PATRIC; fig|411483.3.peg.1836; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000004619; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000004619};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:EEU96347.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004619}.
FT   DOMAIN        5    100       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      124    343       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   407 AA;  44918 MW;  22EFDD0650A6C06D CRC64;
     MAVVISVSAL NRYVKNLLDV NDVLFDLALR GEIANFVQNA RSGHCYFSLR DEAASVRAVM
     FRSDARRLGF QPEEGMKVVV RCRVTLYERD GAFQVYVNDM FPDGIGSTQL AFEQLKAKLD
     KEGLFAPEHK KPLPRFPQCI GLVTSKTGAA LQDIRNVIGR RWPAVRLLLA PVNVQGFEAA
     EEIADAITRL DKSGLVDEII VARGGGSRED LWVFNAEVIA RAAYRCKTPL ISAIGHEIDF
     TILDFVADQR APTPSAAAEL AVPDRAEQGR KLCTLEENIH NCIQFKLSLC YNRLEQTEQL
     LSRAGVQAAL EERAARLDTL AGRLQTAARG KLQAGELRLK HTAALAASLN PYGVLARGYA
     MVQDNRGRIC TPDALRPGQT CKLRGTEHRV TCTVNTVEEL DESTQKL
//
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