ID AB46G_ORYSJ Reviewed; 1440 AA.
AC C7J6G6; B9G2Z6;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=ABC transporter G family member 46 {ECO:0000303|PubMed:18299247};
DE Short=OsABCG46 {ECO:0000303|PubMed:18299247};
DE AltName: Full=Pleiotropic drug resistance protein 21 {ECO:0000303|PubMed:16506311};
DE Short=OsPDR21 {ECO:0000303|PubMed:16506311};
GN Name=ABCG46 {ECO:0000303|PubMed:18299247};
GN Synonyms=PDR21 {ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os09g0332360 {ECO:0000312|EMBL:BAH94510.1},
GN LOC_Os09g16290; ORFNames=OsJ_28924 {ECO:0000312|EMBL:EEE69493.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH94510.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE69493.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP008215; BAH94510.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000146; EEE69493.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; C7J6G6; -.
DR SMR; C7J6G6; -.
DR STRING; 39947.C7J6G6; -.
DR PaxDb; 39947-C7J6G6; -.
DR eggNOG; KOG0065; Eukaryota.
DR InParanoid; C7J6G6; -.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000007752; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR PANTHER; PTHR48040:SF40; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48040; PLEIOTROPIC DRUG RESISTANCE PROTEIN 1-LIKE ISOFORM X1; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1440
FT /note="ABC transporter G family member 46"
FT /id="PRO_0000433456"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 659..679
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 745..765
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1188..1208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1219..1236
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 1271..1291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1302..1322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1332..1352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 137..419
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 497..710
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 843..1095
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1168..1382
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 888..895
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1440 AA; 162399 MW; 26B183A00CBEEC23 CRC64;
MDDDVDAGEI YAVDRQREEG SASAAAFSRS PSTGRVDDDD DDLLTYGRSA RRMAALPAPA
MPEGTELRRP VGGDVVGDDD YLRFLYKFKE LFDRVGIKLP TIEVRYKNLN VEAESYVGSR
GLPTILNTYA NILKGLANTL HMTTRSKQKI SVLHNASGII KPHRMTLLLG SPGSGKTSLL
LALAGTLPST VKVSGMITYN GHTMDKFIPQ RSAAYVSQHD LHMAELTVRE TINFSAKCQG
VGHHYDLFLE LLRREEEENI TPDPETDIYL KAATTGEEKA EIVTNHILKI LRLDICADTI
VGDNMLRGIS GGQKRCLDAH TAPNVDSAAE MLVTLGRALF MDEISNGLDS STTFQIVNTI
QQTIHVLGGT AVIALLQPAP ETYELFDDII LLSDGQVVYS GPRDHVLEFF KSLGFKCLER
IGVADFLQEV TSRKDQKQYW IHGDDTYRYI PVTVIAEAFQ CFHVGQAIRS ELAIPFDNSK
SHIAALKTSK HGVNLKKILK ANIDREILLL KRKSFLYIFN ALQLTLVAII AMSVFIHTNM
HHDSIENGRM YMGVQFFGTL AIMFKGLAEM GAALANLPVF FKQRDLLFYP AWTYSLPSWI
IKTPISFLNT IIWVSITYYV IGFDPNIERC FRQFLVLFVM SEAICGLFRF IAALTRHPVV
ASTVSEFCIL IVMVSSGFIL SRDEVKKWLI WEYWTSPLMY ALNALAVNEF LSPSWNEALP
GFREPLGRLV LESRGVFPEA KWYWIGLGAL LGYVLLFNIL YTICLSILTL LKRNVREMSQ
ETLQIKLENL TGYDQEPSSG GRVTNDKRYT EGGNNDEATS SNANHNSSPA RKGSILPFVP
VYMTFEDIRY SIDMPKALKV QGMAGSRLEL LKDLSGSFRP GVLTALMGIS GAGKTTLLDV
LAGRKTSGHI HGNITVSGYP KKQETFSRVS GYCEQNDIHS PNLTVYESLM FSAWLRLPAE
IDSMARKRFI DEFMELVELF PLKDALVGLL GLSGLSTEQR KRLTIAVELV ANPSIIFMDE
PTSGLDARAA AIVMRTVRNI VDMGRTVVCT IHQPSIDIFE SFDELFLMKR GGEAIYVGPL
GQHSCELIKY FESIEGVRKI KHGYNPSTWM LEVTCTLQEQ ITGVNFTQVY KNSELYRRNK
NLIKELSTPH DGSSDLLFPT KYSQTFVIQC LACLWKQRLS YWRNPPYIAV NFFFTVVIAL
LFGTMFWGVG RKRQSQQALL SAMGSMYSTC FTLGVQNSSS VQPVVNIERT VFYRERASHM
YSPLPYALGQ VVVELPYIFL QTLIYGVIVY SMMGYEWTCT KFFWYMFFMY FTLSYFTFYG
MMAAGLTPNY TMSSIVSTTF YAIWHLFSGF LIPKTRIPIW WRWYYWICPV AWTINGLVTS
QFGDVDDKFD NGVRVSDFVE SYFGYNLDLL WVAAMAVVSF AILFAILFGF SLKLFNFQKR
//
