ID C7MDA5_BRAFD Unreviewed; 787 AA.
AC C7MDA5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ComEC/Rec2-related protein {ECO:0000313|EMBL:ACU85562.1};
GN OrderedLocusNames=Bfae_17410 {ECO:0000313|EMBL:ACU85562.1};
OS Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG
OS 19847 / NBRC 14762 / NCIMB 9860 / 6-10).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=446465 {ECO:0000313|EMBL:ACU85562.1, ECO:0000313|Proteomes:UP000001919};
RN [1] {ECO:0000313|EMBL:ACU85562.1, ECO:0000313|Proteomes:UP000001919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 /
RC NCIMB 9860 / 6-10 {ECO:0000313|Proteomes:UP000001919};
RX PubMed=21304631; DOI=10.4056/sigs.492;
RA Lapidus A., Pukall R., Labuttii K., Copeland A., Del Rio T.G., Nolan M.,
RA Chen F., Lucas S., Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S.,
RA Rohde M., Goker M., Pati A., Ivanova N., Mavrommatis K., Chen A.,
RA Palaniappan K., D'haeseleer P., Chain P., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Brachybacterium faecium type strain
RT (Schefferle 6-10).";
RL Stand. Genomic Sci. 1:3-11(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001643; ACU85562.1; -; Genomic_DNA.
DR RefSeq; WP_015775771.1; NC_013172.1.
DR RefSeq; YP_003155152.1; NC_013172.1.
DR AlphaFoldDB; C7MDA5; -.
DR STRING; 446465.Bfae_17410; -.
DR KEGG; bfa:Bfae_17410; -.
DR PATRIC; fig|446465.5.peg.1728; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_4_0_11; -.
DR OrthoDB; 7177610at2; -.
DR Proteomes; UP000001919; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001919};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 228..495
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 536..602
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 787 AA; 80892 MW; FDF9D855A4CE91C2 CRC64;
MTRSDLRLLP GATCVWALAV LGVTAGTAAA VAGGAVLVAL ALTAITLMGR TRLAHGIYAH
LGIIVLAGVL LFPALQRHGG TAEAFEDAAE QGLIVELTVA AAADPAVPDS GPQWSRSGQQ
MRARTVRGPA RMGRDAVTLP ASVPVLVRAS GTTGHELARV RDGDRVHLRG RAAVSGSLVV
LRATEVHPVV AGGFAGAAQT ARHDLRHQAR QATDHLPRDD AALVRGMSIG DTRGLGEEAE
EIMRRAGISH LVAVSGANIA LVLAAVLGPL LLLGVRRRPR LLAAGILMAG YLWLVGDEPS
VQRAATMVTP LLAARFAGIR ASPVAALALT VALWSVIDPV TAASVGFLLS GLATAAILIA
APPLATALVE LSGERIGRTT ALVLAVPLVA QLACTPVLVL LTPEISLWAV PVNMIVGPLV
GPTTVIGLLA LVLGTVWPAA AALLWSVAAG GAHLVLLIAR AADALPGSRI AVPEGATGAV
LAVGALLAAT IAVAARRRPL VRWAVAALLV AVLAPGAARL VPLGTAPPWT LALCAVGQGD
AVLLRARPSD RDAPIVLLDT GPDPEALRQC LDRLQIPRID LLVLTHPHQD HTGGRAALTG
RRAPAQQWVC PLPKASRDVA PSAPVTVATT GQTWQRPGLR LRVLWPGSAE DAHRASAAEQ
SAGAGDAAND CSVTLEAVWE DGTRLVALGD LEPAAQTELT AGGPGPADIV KVAHHGSRFQ
HASLYEELDA DLALVPVGRD NDFGHPTDEL LDLLHTTGTR ILRTDVHGTV ILPADGSSSP
RSVGPAR
//
